Sort   by:  
 Page size 
ProteomicsA proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimers disease
State-of-the-art mass spectrometry (MS) methods can comprehensively detect proteomic alterations in neurodegenerative disorders, providing relevant insights unobtainable with transcriptomics investigations. Analyses of the relationship between progressive aggregation and protein abundance changes in...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-21 | PXD030348 | Pride
Mouse model Amyloidogenesis Proteomics Alzheimers disease 5xfad 
OtherQuantitative interaction proteomics of neurodegenerative disease proteins.
Data from ProteomeXchange, PXD ID: PXD001942. File: 20130829_Orbi6_FaHo_SA_NN_SWEvsEV_Rep3_01.mzml. Published as part of Cell Rep. 2015 May 19;11(7):1134-46 . From the Abstract: {{i}} Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not comple...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320018141 | GPMDB
Resource Reanalysis 
TranscriptomicsGene expression data from cortex of 9 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38218 | biostudies-arrayexpress
TranscriptomicsGene expression data from cortex of 15 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38219 | biostudies-arrayexpress
ProteomicsEnabling phenotypic drug discovery for neurological mitochondrial DNA disorders with patient-derived neural progenitor cells
Mitochondrial DNA (mtDNA) mutations predominantly cause neurological diseases. Searching for therapeutic strategies is hindered by the absence of viable neural model systems due to the challenges of engineering mtDNA. We demonstrate that neural progenitor cells (NPCs), rapidly obtained from human in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080849 | MassIVE
Sort   by:  
 Page size