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GenomicsWapl controls higher-order chromatin structure in interphase chromosomes (ChIP-Seq)
Mammalian genomes contain several billion base pairs of DNA which are packaged in chromatin fibers. At selected gene loci, cohesin complexes have been proposed to arrange chromatin fibers into higher-order structures, but it is poorly understood how cohesin performs this task, how important this fun...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-41602 | biostudies-arrayexpress
GenomicsChIP-seq data for WAPL in ZFP661 overexpression mESCs
ChIP-seq data for WAPL in ZFP661 overexpression mESCs
PRJNA1230118 | ENA
TranscriptomicsWapl controls higher-order chromatin structure in interphase chromosomes (gene expression)
Mammalian genomes contain several billion base pairs of DNA which are packaged in chromatin fibers. At selected gene loci, cohesin complexes have been proposed to arrange chromatin fibers into higher-order structures, but it is poorly understood how cohesin performs this task, how important this fun...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-41460 | biostudies-arrayexpress
TranscriptomicsBudding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [BrdU-ChIP].
Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-22 | E-GEOD-42456 | biostudies-arrayexpress
UnknownStructure of the human cohesin inhibitor Wapl.
Not available
S-EPMC3710786 | biostudies-literature
GenomicsDecreasing Wapl dosage partially corrects transcriptome phenotypes in Nipbl-/+ embryonic mouse brain
Decreasing Wapl dosage partially corrects transcriptome phenotypes in Nipbl-/+ embryonic mouse brain
PRJNA838015 | ENA
UnknownSororin is an evolutionary conserved antagonist of WAPL.
Not available
S-EPMC11148194 | biostudies-literature
GenomicsComparison of gene expression in the cervix of wild-type and WAPL Tg mice
Comparison of gene expression in the cervix of wild-type and WAPL Tg mice
PRJNA716739 | ENA
UnknownWAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7.
Not available
S-EPMC8154587 | biostudies-literature
UnknownA kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.
Not available
S-EPMC5757254 | biostudies-literature
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