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MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
ProteomicsRe-evaluation of the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: CIAPIN1 is a major target of VLX1570 for non-selective covalent modification and aggregation in a multiple myeloma model.
Deubiquitinating enzymes are a growing target class across multiple disease states, with several inhibitors now reported. b-AP15 and VLX1570 are two structurally related USP14/UCH-37 inhibitors. Initially taken forward into a phase I/II clinical trial for refractory Multiple Myeloma, VLX1570 has sin...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD015412 | Pride
Proteomics Vlx1570 Chemoproteomics Bap-15 Multiple myeloma 
TranscriptomicsThe Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast
The experimental evolution of laboratory populations of microbes provides an opportunity to observe the evolutionary dynamics of adaptation in real time.Until very recently, however, such studies have been limited by our inability to systematically find mutations in evolved organisms.We overcome thi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-13435 | biostudies-arrayexpress
ProteomicsCombined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis
The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment response has hampered the development of new therapies for amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disorder with a variable site of disease initiation and rate of pr...
ORGANISM(S): Homo sapiens (Human) 
2020-07-30 | PXD020493 | Pride
Pbmc Als Tmt Tmtcalibrator 
TranscriptomicsTranscription profiling time series of leaves from winter wheat grown under S and N-deficient conditions
Transcripomic analysis of leaf gene expression in S and N-deficient winter wheat during grain development. Tissue was harvested at anthesis and 7, 14 and 21 days post anthesis from experimental field plots.
ORGANISM(S): Triticum aestivum 
2008-09-18 | E-MEXP-1415 | biostudies-arrayexpress
GenomicsEpigenetic comparison of human DNA in specific human tissues to human DNA in transgenic mouse tissues
This project aims to study human repetitive elements on human chromosome 21 (HsChr21) in a heterologous mouse environment (Tc1 mouse). The in vivo, HsChr21-wide enrichment of active histone modified regions (H3K4me3) and transcription factor binding sites was profiled by ChIP-seq in Human and Tc1 mo...
ORGANISM(S): Mus musculus 
2013-03-21 | E-MTAB-1104 | biostudies-arrayexpress
MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
UnknownLong-Term Mortality Following SARS-CoV-2 Infection in Rural Versus Urban Dwellers With Autoimmune or Inflammatory Rheumatic Disease: A Retrospective Cohort Analysis From the National COVID Cohort Collaborative.
Not available
S-EPMC11693476 | biostudies-literature
UnknownPrehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial.
Not available
S-EPMC6497986 | biostudies-literature
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