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TranscriptomicsExpression of SUDHL-1 cell line treated by ALK inhibitors
In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-50803 | biostudies-arrayexpress
TranscriptomicsDiagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)
Cutaneous T-cell lymphomas (CTCL) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult due to a clinical and histological resemblance to benign inflammatory skin diseases. To address if microRNA (miRNA) profiling can discriminate CTCL from benig...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31408 | biostudies-arrayexpress
TranscriptomicsNPMâ??ALK permits the survival of thymic T cells with aberrant T cell receptor rearrangements enabling thymic escape and tumor development
We present evidence to support a new model of Anaplastic Large Cell Lymphoma (ALCL) pathogenesis in which the malignancy is initiated in early thymocytes, prior to TCR rearrangement which is bypassed in NPMâ??ALK transgenic mice following Notch1 expression. In support, we show that T cell receptor (...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-67131 | biostudies-arrayexpress
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