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TranscriptomicsDifferential gene expression by NKX2-1 suppression in NCI-H2009 cells
The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To better understand how genomic alterations of NKX2-1 drive tumorigenesis, we generated an expression signature associated with NKX2-1 amplification in hum...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-GEOD-40270 | biostudies-arrayexpress
GenomicsNKX2-1 occupancy in human lung adenocarcinoma cell lines
The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To better understand how genomic alterations of NKX2-1 drive tumorigenesis, we generated an expression signature associated with NKX2-1 amplification in hum...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-39998 | biostudies-arrayexpress
GenomicsDynamic epigenetic regulation by menin during pancreatic islet tumor formation
loss of Men1 in mouse pancreatic islet cells alters the epigenetic landscape of a subset of target genes. H3K4me3 ChIP-seq from either mouse pancreatic islets or mouse pancreatic islet tumors harvested at different stages.
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-63020 | biostudies-arrayexpress
GenomicsSOX2 and p63 occupancy in human squamous carcinoma cell lines and embryonic stem cells.
SOX2 is a transcription factor essential for pluripotent stem cells, and development and maintenance of squamous epithelium. We previously reported SOX2 an oncogene subject to highly recurrent genomic amplification in squamous cell carcinomas (SCCs). Here we demonstrate in SCCs that SOX2 interacts ...
ORGANISM(S): Homo sapiens 
2014-03-12 | E-GEOD-46837 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression by suppression of either SOX2 or TP63 in KYSE70 human esophageal squamous carcinoma cell line.
SOX2 is a transcription factor essential for pluripotent stem cells, and development and maintenance of squamous epithelium. We previously reported SOX2 an oncogene subject to highly recurrent genomic amplification in squamous cell carcinomas (SCCs)1. Here we demonstrate in SCCs that SOX2 interacts...
ORGANISM(S): Homo sapiens 
2014-05-13 | E-GEOD-47058 | biostudies-arrayexpress
TranscriptomicsSuperSAGE data from skunk cabbage spadices
This study aims at investigating the gene expression profile of thermogenic skunk cabbage (Symplocarpus renifolius). Using Super-SAGE, we compared the gene expression profile of different developmental stages of skunk cabbage spadices. To obtain the SuperSAGE libraries, we followed the original Sup...
ORGANISM(S): Symplocarpus renifolius 
2011-12-22 | E-GEOD-29852 | biostudies-arrayexpress
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
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