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ProteomicsTranscriptomic and Proteomic Signatures of Stemness and Differentiation in the Colon Crypt
The intestinal epithelium is replaced weekly by non-quiescent stem cells with kinetics that rely on a rapid loss of stemness and choice for secretory or absorptive lineage differentiation. To determine how the cellular transcriptome and proteome changes during these transitions, we developed a new c...
ORGANISM(S): Mus Musculus (mouse) 
2020-07-15 | PXD019351 | JPOST Repository
GenomicsWhole-genome nucleosome mapping in meiotic diploid S. cerevisiae
We determined nucleosome positions throughout the genome in diploid S. cerevisiae undergoing early stages of synchronous meiosis. This study sought to assess if systematic reorganization of nucleosomes occurs during meiotic prophase at or near sites of DNA double strand break formation. Six samples ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-07 | E-GEOD-26452 | biostudies-arrayexpress
TranscriptomicsThe effects of the 5' pocket motif of Dicer on miRNA biogenesis
A hallmark of RNA silencing is a class of ~22 nt RNAs which are processed from dsRNA precursor by Dicer. Accurate processing by Dicer is critical for the functionality of microRNAs (miRNAs). According to the current model, Dicer measures the length by anchoring the 3' overhang of the dsRNA terminus....
ORGANISM(S): Mus musculus 
2011-07-12 | E-GEOD-27903 | biostudies-arrayexpress
TranscriptomicsEmbedding siRNA sequences targeting Apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy
Purpose: Identical predicted small interfering RNA (siRNA) sequences targeting Apolipoprotein B100 (siApoB) were embedded in shRNA (shApoB) or miRNA (miApoB) scaffolds and a direct compariso of the possible aspecific off-target effects in vivo was performed. Next generation sequencing (NGS) of smal...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-39187 | biostudies-arrayexpress
UnknownThe effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study.
Not available
S-EPMC11754546 | biostudies-literature
UnknownA novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.
Not available
S-EPMC4248067 | biostudies-literature
UnknownA Wnt kinase network alters nuclear localization of TCF-1 in colon cancer.
Not available
S-EPMC2787979 | biostudies-literature
TranscriptomicsDNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements and chimaeric transcripts in mouse ES cells
DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing of genes and retroelements. However, a comprehensive comparison of genes and repetitive elements repressed by these pathways has not been reported. Here we show that in mouse embryonic stem cells (mESC...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29413 | biostudies-arrayexpress
UnknownFunctional SARS-CoV-2-specific immune memory persists after mild COVID-19.
Not available
S-EPMC7430600 | biostudies-literature
UnknownFunctional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.
Not available
S-EPMC7682481 | biostudies-literature
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