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ProteomicsPredictive modelling of brain metastasis development from cancer and non-invasive biomarker-based risk assessment leveraging DNA methylation signatures
Brain metastases (BM) are the most common and among the most deadly brain tumors. Currently, there are no reliable predictors of BM development from primary cancer, limiting early intervention. Here, we obtained 364 tumor/plasma samples from a large cohort of lung adenocarcinoma (LUAD) and BM patien...
ORGANISM(S): Homo sapiens (Human) 
2025-03-21 | PXD048525 | Pride
Brain metastases Lung adenocarcinoma Dna methylation Proteomics Biomarkers 
MetabolomicsAccumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex
Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that in Arabidopsis thaliana, scopolin accumulation can be in...
2018-02-05 | MTBLS389 | MetaboLights
TranscriptomicsA Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Recovery phase
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to gre...
ORGANISM(S): Pimephales promelas 
2012-09-20 | E-GEOD-36466 | biostudies-arrayexpress
TranscriptomicsA Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Exposure Phase
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to gre...
ORGANISM(S): Pimephales promelas 
2012-09-20 | E-GEOD-36465 | biostudies-arrayexpress
ProteomicsMulti-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled by analysis of gene copy number variation, whole exome sequence, methylome, transcriptome, proteome, and phospho(Tyr)-proteome. Proteome profiling resolved the known major histology subtypes and r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-11-24 | PXD016579 | Pride
Nsclc Tmt Lung Pdx 
TranscriptomicsEffects of the anti-microbial contaminant triclocarban on the reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas)
Triclocarban (TCC) is a widely used antimicrobial agent that is routinely detected in surface waters. The present study was designed to examine TCC’s efficacy and mode of action as a reproductive toxicant in fish. Reproductively mature Pimephales promelas were continuously exposed to either 1 or 5 μ...
ORGANISM(S): Pimephales promelas 
2015-07-31 | E-GEOD-64291 | biostudies-arrayexpress
Proteomics6 Ocotea sp. dataset analyzed in DIA mode (ESI positive and negative)
This dataset consists of 6 Ocotea plant species analyzed in negative and positive modes, with data-independent acquisition (MSe), in a Waters Xevo G2 instrument. The available data were converted in .mzML format using the Waters2mzML software, available on Github. Detailed information about data a...
ORGANISM(S): Ocotea Lancifolia (ncbitaxon:881603) Ocotea Guianensis (ncbitaxon:128661) Ocotea Odorifera (ncbitaxon:128668) Ocotea Diospyrifolia (ncbitaxon:881600) Ocotea Porosa (ncbitaxon:1365881) Ocotea Notata 
2024-02-07 | MSV000094030 | MassIVE
MetabolomicsPlasmid-encoded toxin defence mediates mutualistic microbial interactions

Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms while enabling the transfer of a diverse array of accessory functions. However, their precise impact on microbial community compo...

2023-08-10 | MTBLS7248 | MetaboLights
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
MetabolomicsWhat CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines

Background: Cell line specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) too. However, a key ingredient, namely an experimentally validat...

2020-07-13 | MTBLS1210 | MetaboLights
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