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GenomicsDiscrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during Helper T Cell Differentiation (ChIP-Seq)
Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood. Using chromatin immunoprecipitation and massive parallel sequencing, we quantitated the full c...
ORGANISM(S): Mus musculus 
2010-06-18 | E-GEOD-22104 | biostudies-arrayexpress
GenomicsGlobal Mapping of Histone H3 K4 and K27 Trimethylation: Lineage Fate Determination of Differentiating CD4+ T Cells
Multipotential naïve CD4+ T cells differentiate into distinct lineages including Th1, Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications ...
ORGANISM(S): Mus musculus 
2009-01-21 | E-GEOD-14254 | biostudies-arrayexpress
TranscriptomicsFurin deficiency efect on T cells
Analysis of T-cells lacking the proprotein convertase furin. Proprotein convertases promote the proteolytic maturation of proproteins. Furin is induced in activated T-cells. Results provide insight into the function of furin in T-cells. CD4+CD62L+CD44- naive, CD4+CD62L-CD44+ memory and CD4+CD25+FoxP...
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-67884 | biostudies-arrayexpress
TranscriptomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1-4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argu...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23505 | biostudies-arrayexpress
TranscriptomicsTpl2 promotes chemokine/chemokine receptor expression and macrophage migration during acute inflammation
In autoimmune diseases, accumulation of activated leukocytes correlates with inflammation and disease progression, and therefore, disruption of leukocyte trafficking is an active area of research. The protein kinase Tpl2 (MAP3K8) regulates leukocyte inflammatory responses and is also being investig...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-48338 | biostudies-arrayexpress
TranscriptomicsDiverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis [Affymetrix Expression]
STAT3, an essential transcription factor with pleiotropic functions, plays critical roles in the pathogenesis of autoimmunity. Despite recent data linking STAT3 with inflammatory bowel disease, exactly how it contributes to chronic intestinal inflammation is not known. Using a T cell transfer model ...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21670 | biostudies-arrayexpress
TranscriptomicsDiscrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during Helper T Cell Differentiation (gene expression)
Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood. Using chromatin immunoprecipitation and massive parallel sequencing, we quantitated the full c...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-22081 | biostudies-arrayexpress
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