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TranscriptomicsActivation of ER-alpha network in MMTV-Wnt/ILK mammary tumors
A transgenic mouse model, MMTV-Wnt/ILK, with mammary specific expression of both Wnt-1 and ILK, was generated by crossing the two mouse lines MMTV-Wnt-1 and MMTV-ILK. Affymetrix Mouse Exon chips were hybridized with material from four independent mammary tumors from each MMTV-Wnt-1 and MMTV-Wnt/ILK ...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-19300 | biostudies-arrayexpress
TranscriptomicsPenfield: Understanding the affect of maternal environment on seed dormancy
Maternal environment is an important regultor of seed dormancy, but the mechanisms underlying the process are poorly understood. We have found that genes in the circadian clock control dormancy, in part through their regulation of the canonical photoperiod pathway known from research into flowering ...
ORGANISM(S): Arabidopsis thaliana 
2011-04-21 | E-GEOD-28747 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis early post-germinative embryo and endosperm
Arabidopsis seed germination is coordinated with the strong induction of metabolic pathways required for the mobilisation and utilization of seed storage reserves. These are essential to support the seedling before the establishment of photoauxotrophic growth. The activity of genes encoding enzymes ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5751 | biostudies-arrayexpress
ProteomicsDirected evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy
Enzymes that oxidize aromatic substrates have shown utility in a range of cell-based technologies including live cell proximity labeling (PL) and electron microscopy (EM), but are associated with drawbacks such as the need for toxic H2O2. Here, we explore laccases as a novel enzyme class for PL and ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-12 | PXD062870 | Pride
Tmt Proximity labeling 
ProteomicsGadd45a Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4
Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly understood at the molecular level. Previous work found that skeletal muscle atrophy involves an increase in skeletal muscle Gadd45a expression, which is necessary and sufficient for skeletal muscle fiber atrophy...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-17 | MSV000079730 | MassIVE
ProteomicsEffect of oxygen tension on MMTV-PyMT tumor cell kinome
Solid tumors are characterized by significantly lower oxygen (O2) levels. Despite this fact, routine preclinical cancer studies are performed under ambient O2 conditions. We have developed an experimental approach that allows us to collect, process and evaluate cancer and non-cancer cells under phys...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-08 | PXD046005 | Pride
Ambient Breast cancer Kinase inhibitor beads Physioxia Lapatinib 
TranscriptomicsmicroRNA-like off-target transcript regulation by siRNAs
siRNAs mediate sequence-specific gene silencing in cultured mammalian cells but also silence unintended transcripts. Many siRNA off-target transcripts match the guide-strand ‘‘seed region,’’ similar to the way microRNAs match their target sites. The extent to which this seed-matched, microRNA-like, ...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-14073 | biostudies-arrayexpress
TranscriptomicsUp-regulation of IFN-related genes in BRCA2-/- cells
Microarray-based expression profiling of BRCA2 knockout and isogenic wild type HCT116 human colorectal cancer cells One way ANOVA, single factor comparison of wild type and BRCA2 knockout cells, three CEL files for wild type, three CEL files for BRCA2 knockout
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-54830 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 27,578 CpG sites to assess epigenetic erasure and restoration due to reprogramming and redifferentiatio...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1275 | biostudies-arrayexpress
TranscriptomicsHigh-resolution methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 485,000 loci to assess epigenetic erasure and restoration due to reprogramming and redifferentiation to...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1274 | biostudies-arrayexpress
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