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MetabolomicsMapping human microbiome drug metabolism by gut bacteria and their genes

Individuals vary widely in their drug responses, which can be dangerous and expensive due to treatment delays and adverse effects. Growing evidence implicates the gut microbiome in this variability, however the molecular mechanisms remain largely unknown. We measured the ability of 76 diverse hum...

2019-07-10 | MTBLS896 | MetaboLights
ProteomicsEx vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized treatments. Here, we survey the ex vivo drug and immun...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-06 | MSV000088992 | MassIVE
MetabolomicsGNPS Metabolomics analysis of 180 cancer cell lines
Metabolome analysis of 180 cancer cell lines. Intracellular extracts. Flow injection analysis - TOF (negative mode, no LC). Sample description is included in Metadata_File_CellLines.txt
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-04 | MSV000087155 | GNPS
ProteomicsHigh-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Glioblastoma, the most aggressive primary brain cancer, has dismal prognosis, yet systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies may emerge from exploring neurodevelopmental and neurophysiological vulnerabilities of glioblastoma. To this end, we here syste...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090357 | MassIVE
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