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MetabolomicsShi Wei Ru Xiang pill alleviates acute gouty arthritis through suppressing NLRP3 inflammasome activation

Shi Wei Ru Xiang pill (SWR) is commonly utilized in Tibetan medicine as a therapeutic intervention for 'Huang-shui disease' and has been clinically validated as an effective treatment for acute gouty arthritis (AGA). Nevertheless, the underlying mechanisms of action and the active components of S...

2025-06-20 | MTBLS12617 | MetaboLights
ProteomicsEGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association
EGF is one of the most well-characterized growth factors and plays a crucial role in cell proliferation and differentiation. EGFR has been extensively explored as a therapeutic target against multiple types of cancers, such as lung cancer and glioblastoma. Recent studies have established a connectio...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD031593 | Pride
Epidermal growth factor (egf) Phosphotyrosine binding protein O-glcnacylation Pyruvate kinase m2 (pkm2) Phosphorylation O-glcnac transferase (ogt) 
ProteomicsCalcineurin-regulated Phosphopeptide(30 min) and CaN-regulated dephosphopeptide(10 min) researchs in Pheromone gland of  Helicoverpa armigera
Calcineurin-regulated Phosphopeptide(30 min) and CaN-regulated dephosphopeptide(10 min) researchs used Itraq method in Pheromone gland of Helicoverpa armigera
ORGANISM(S): Helicoverpa armigera (Cotton bollworm) 
2017-10-10 | PXD006380 | Pride
Proteomics Helicoverpa armigera Pheromone gland (de)phosphopeptides Itraq 
ProteomicsPKM2 functions as a histidine kinase to phosphorylate PGAM1 to increase glycolysis shunts in cancer-Cellular lipid level assessment
Phosphoglycerate mutase 1 (PGAM1) is a key node enzyme that diverts the metabolic reactions from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation. It is prevalent that PGAM1 activity is upregulated in various tumors; however, the underlyin...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049310 | Pride
Glycolysis shunts Pyruvate kinase m2 (pkm2) Histidine kinase Phosphorylation Phosphoglycerate mutase 1 (pgam1) 
ProteomicsPKM2 functions as a histidine kinase to phosphorylate PGAM1 to increase glycolysis shunts in cancer
Phosphoglycerate mutase 1 (PGAM1) is a key-node enzyme that diverts the metabolic intermediates from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation. It is prevalent that PGAM1 activity is upregulated in various tumors; however, the under...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049235 | Pride
Glycolysis shunts Pyruvate kinase m2 (pkm2) Histidine kinase Phosphorylation Phosphoglycerate mutase 1 (pgam1) 
MetabolomicsNon-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome
INTRODUCTION: Neonatal cholestatic disorders are a group of hepatobiliary diseases occurring in the first 3 months of life. The most common causes of neonatal cholestasis are infantile hepatitis syndrome (IHS) and biliary atresia (BA). The clinical manifestations of the two diseases are ...
2019-06-25 | MTBLS689 | MetaboLights
TranscriptomicsInteraction with Human Bronchial Epithelial Cells in vitro Affects Gene Expression in Moraxella catarrhalis
In this study, DNA microarray technology was used to measure global gene expression in M. catarrhalis cells that had attached to human bronchial epithelial cells in culture. M. catarrhalis ATCC 43617 was allowed to attach (MOI~30) to a monolayer of 16HBE14 human bronchial epithelial cells for 2 hr i...
ORGANISM(S): Moraxella catarrhalis 
2014-03-24 | E-GEOD-12990 | biostudies-arrayexpress
TranscriptomicsCellular responses to the oxidizing effects of bleach
E. coli MG1655 was grown in MOPS minimal glucose medium at 37 degrees C with aeration to an OD600 of 0.4 - 0.5, and HOCl was added to a final concentration of 400 ?M. 0.5 ml samples were collected in liquid nitrogen immediately before, 5 min after, and 10 min after HOCl addition, and total RNA was p...
ORGANISM(S): Escherichia coli 
2013-04-10 | E-MEXP-3639 | biostudies-arrayexpress
TranscriptomicsTime course microarray data following GR activation in MCF10A-Myc breast cells
This series contain time course microarray data from MCF10A-Myc cells treated with either ethanol or Dexamethasone for 30 min, 2 hr, 4 hr, and 24 hr. This series contains three biological replicates that were analyzed as independent replicate experiments (data were normalized within each replicate e...
ORGANISM(S): Homo sapiens 
2006-06-01 | E-GEOD-4917 | biostudies-arrayexpress
ProteomicsLactylation in Diabetic Cardiomyopathy
Lysine lactylation (Kla), is a newly found post-translational modification that has been found to be involved in the pathogenesis of many diseases. However, the specific effect of protein lactylation has not been reported on the development of diabetic cardiomyopathy (DCM). Here, the purpose of this...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD067368 | Pride
Lactylome  proteome  protein lactylation  diabetic cardiomyopathy 
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