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UnknownIncorporating uncertainty in Indigenous sea Country monitoring with Bayesian statistics: Towards more informed decision-making.
Partnerships in marine monitoring combining Traditional Ecological Knowledge and western science are developing globally to improve our understanding of temporal changes in ecological communities that better inform coastal management practices. A fuller communication between scientists and Indigenou...
S-EPMC10992390 | biostudies-literature
UnknownCell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets.
Whether a cell lives or dies is controlled by an array of intercepting and dynamic molecular pathways. Although there is evidence of neuronal loss in Alzheimer's disease (AD) and multiple programmed cell death (PCD) pathways have been implicated in this process, there has been no comprehensive evalu...
S-EPMC7609561 | biostudies-literature
GenomicsEpigenetic Profiling of Human Colorectal Cancer

DNA methylation, together with chromatin modifications, constitute the epigenome that functions to regulate gene expression and genome integrity. DNA methylation alterations are ubiquitous in human cancers, as many genes acquire DNA methylation in a cancer-specific manner. DNA methylation at thes...

phs000385.v1.p1 | EGA
UnknownIntegrated DNA Methylation/RNA Profiling in Middle Temporal Gyrus of Alzheimer's Disease.
Alzheimer's disease is a neurodegenerative disorder clinically defined by gradual cognitive impairment and alteration in executive function. We conducted an epigenome-wide association study (EWAS) of a clinically and neuropathologically characterized cohort of 296 brains, including Alzheimer's disea...
S-EPMC10287777 | biostudies-literature
UnknownFluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues.
Molecular clocks that record cell ancestry mutate too slowly to measure the short-timescale dynamics of cell renewal in adult tissues. Here, we show that fluctuating DNA methylation marks can be used as clocks in cells where ongoing methylation and demethylation cause repeated 'flip-flops' between m...
S-EPMC9110299 | biostudies-literature
UnknownIdentification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features.
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq) to distinguish post-mitotic cone and rod developmental state...
S-EPMC12327943 | biostudies-literature
UnknownIdentification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features.
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq) to distinguish post-mitotic cone and rod developmental state...
S-EPMC11195049 | biostudies-literature
UnknownCombination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand up 2 cancer study.

Purpose

Therapy with demethylating agent 5-azacitidine and histone deacetylase inhibitor entinostat shows synergistic re-expression of tumor-suppressor genes and growth inhibition in colorectal (CRC) cell lines and in vivo studies.

Experimental design

We conducted a phase II, multi-in...
S-EPMC5471058 | biostudies-literature
UnknownAlterations of immune response of Non-Small Cell Lung Cancer with Azacytidine.
Innovative therapies are needed for advanced Non-Small Cell Lung Cancer (NSCLC). We have undertaken a genomics based, hypothesis driving, approach to query an emerging potential that epigenetic therapy may sensitize to immune checkpoint therapy targeting PD-L1/PD-1 interaction. NSCLC cell lines were...
S-EPMC3875770 | biostudies-literature
UnknownDetection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas.
Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification of patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring. In this study, we analyze the DNA methylation lev...
S-EPMC10499807 | biostudies-literature
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