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UnknownValidation of reference genes for quantitative real-time PCR during leaf and flower development in Petunia hybrida.
Not available
S-EPMC2827423 | biostudies-literature
TranscriptomicsGATA-1-regulated erythroid microRNAs
We employed a gene complementation strategy combined with microarray screening to identify miRNAs involved in the formation of erythroid (red blood) cells. To search for GATA-1-regulated erythroid miRNAs, we used the Gata-1– erythroblast line G1E. These cells proliferate in culture as immature ery...
ORGANISM(S): Mus musculus 
2008-02-05 | E-GEOD-10134 | biostudies-arrayexpress
TranscriptomicsExpression data from trisomy 21 and euploid induced pluripotent stem cell hematopoietic progenitors
We modeled human Trisomy 21 primitive hematopoiesis using induced pluripotent stem cells (iPSCs). Primitive multipotent progenitor populations generated from Trisomy 21 iPSCs showed normal proliferative capacity and megakaryocyte production, enhanced erythropoiesis and reduced myeloid development c...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-35561 | biostudies-arrayexpress
GenomicsEpigenetic and genetic features that lead to discovery of enhancer function
The ability to measure epigenetic features, such as histone modifications and occupancy by transcription factors and co-activators, on a genome-wide scale is advancing the accuracy of CRM predictions. While integration of signals from multiple features is expected to improve predictions, the contrib...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-61349 | biostudies-arrayexpress
TranscriptomicsDynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis
We used mouse ENCODE data along with complementary data from other laboratories to study the dynamics of occupancy and the role in gene regulation of the transcription factor TAL1, a critical regulator of hematopoiesis, at multiple stages of hematopoietic differentiation. We combined ChIP-seq and RN...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-51338 | biostudies-arrayexpress
UnknownTherapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma.
Not available
S-EPMC10870201 | biostudies-literature
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FL...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-49664 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1)...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-51337 | biostudies-arrayexpress
GenomicsInsights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis
The transcription factor GATA-1 is required for terminal erythroid maturation and functions as an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability to distinguish between activated versus repressed genes remain incompletely understood. In this study, we p...
ORGANISM(S): Mus musculus 
2009-11-25 | E-GEOD-16594 | biostudies-arrayexpress
TranscriptomicsEffect of heat stress on developing wheat grain
effect of post anthesis heat stress on transcriptome of developing wheat grain
ORGANISM(S): Triticum aestivum 
2019-12-19 | E-MTAB-8520 | biostudies-arrayexpress
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