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ProteomicsMass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis
mass spectrometry analysis of aged and adult hematopoietic stem cells, multipotent progenitors and oligopotent progenitors
ORGANISM(S): Mus musculus (Mouse) 
2021-07-24 | PXD017442 | Pride
Hematopoiesis Early blood progenitors Stem cells Hematopoietic stem cells Aging 
GenomicsClonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Acute myeloid leukemia is an aggressive clonal malignancy of the bone marrow that is the direct result of sequential acquisition of mutations in a single lineage of cells. In this study, we investigate a model in which this mutational acquisition occurs serially in long-lived self-renewing hemato...

phs000549.v1.p1 | EGA
TranscriptomicsDNA methylation data from mouse hematopoietic progenitors
Genome-wide DNA methylation was studied to determine the methylome map of lymphoid and myeoloid commitment from hematopoietic progenitors We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in FACs purified mouse hematopoietic progeniors We isolated genomic DNA from mou...
ORGANISM(S): Mus musculus 
2010-08-14 | E-GEOD-23110 | biostudies-arrayexpress
TranscriptomicsDynamic developmental signaling logic underlying lineage bifurcations during human endoderm induction and patterning from pluripotent stem cells [Endoderm RNA-seq and ChIP-seq data sets]
Unraveling complex signaling programs animating developmental lineage-decisions is pivotal to differentiate human pluripotent stem cells (hPSC) into pure populations of desired lineages for regenerative medicine. Developmental signals are strikingly temporally dynamic: BMP and Wnt initially specify ...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-52657 | biostudies-arrayexpress
TranscriptomicsNeonatal Skeletal Progenitors
Prospectively isolated and characerized skeletal progenitor lineages 3 repeats per FACS sorted population
ORGANISM(S): Mus musculus 
2015-01-29 | E-GEOD-64447 | biostudies-arrayexpress
TranscriptomicsA comprehensive methylome map of lineage commitment from hematopoietic progenitors
Epigenetic modifications must underlie lineage-specific differentiation since terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged. Hematopoiesis provides a well-defined model of progressive differentiation in which to study the role of epigenetic modifi...
ORGANISM(S): Mus musculus 
2010-08-15 | E-GEOD-20244 | biostudies-arrayexpress
UnknownLong-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.
Not available
S-EPMC9857594 | biostudies-literature
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