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UnknownA mass-balance model to assess arsenic exposure from multiple wells in Bangladesh.
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S-EPMC8989717 | biostudies-literature
TranscriptomicsGene expression analyses of SMAD4 knockdown in pancreatic cell line
The transforming growth factor ? (TGF-?) signaling protein SMAD4 is lost in 60% of PDAC, and this has been associated with poorer prognosis. We expressed SMAD4 in human PDAC cell lines BxPC3, by selection of stable clones containing an inducible SMAD4 Tet-ON construct. After 24h of SMAD4 expression,...
ORGANISM(S): Homo sapiens 
2015-08-20 | E-GEOD-70940 | biostudies-arrayexpress
TranscriptomicsNetwork Analysis Reveals a Novel Role for the AP-1 Transcription Factor JUNB in Classical and Alternative Macrophage Activation
Bone marrow-derived macrophages were generated from wild type and Junb knockout mice and tested for their responses to LPS treatment. Independent replicate wells from wild type and knockout bone marrow-derived macrophages were mock-treated or LPS-treated. RNA was isolated at 4 h post-treatment, ampl...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-50542 | biostudies-arrayexpress
TranscriptomicsSalmon Macrophage early response to Aeromonas salmonicida
Aeromonas salmonicida is a fish pathogen that causes furunculosis. Virulent strains of this bacterium are able to infect salmonid macrophages and survive within them, although mechanisms favouring intracellular survival are not completely understood. It is known that A. salmonicida cultured in vivo ...
ORGANISM(S): Salmo salar 
2010-05-26 | E-GEOD-8526 | biostudies-arrayexpress
TranscriptomicsGene expression signatures of HO-1 in BeWo cells
Heme Oxygenase-1 (HO-1) is expressed in many cancers and influences the growth, survivall and metastasis of tumors, however, the molecular mechanisms remains largely unknown. To identify a common mechanism of action of HO-1 in cancer, we studied the global effect of HO-1 on the transcriptome of mul...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-20404 | biostudies-arrayexpress
TranscriptomicsRole of ndvB on gene expression in Pseudomonas aeruginosa
ndvB is a gene expressed preferrentialy in biofilms of Pseudomonas aeruginosa and has been implicated in antibiotic resistance. This gene also has a role in signaling in some plant pathogens. A knockout ndvB strain was used to determine if it controlled any other gene expression related to antibioti...
ORGANISM(S): Pseudomonas aeruginosa PA14 
2012-04-25 | E-GEOD-32032 | biostudies-arrayexpress
TranscriptomicsGene expression changes with inducible expression of activated ras and ras effector domain mutants
The goals of this study were to identify gene transcription changes in cells expressing activated H-RasV12 or activated versions of the ras effector domain mutants RasV12G37, RasV12S35, and RasV12C40 for the purpose of identifying common or unique transcription alterations in cells transformed by di...
ORGANISM(S): Homo sapiens 
2008-08-01 | E-GEOD-8916 | biostudies-arrayexpress
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsEvidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function
Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycerol-2-phosphatidylcholine (PAPC), referred to as OxPAPC, accumulate in atherosclerotic lesions and regulate over 1000 genes in human aortic endothelial cells (HAEC). We previously demonstrated that OxPAPC covalently binds to a number of prote...
ORGANISM(S): Homo sapiens 
2012-02-14 | E-GEOD-35709 | biostudies-arrayexpress
TranscriptomicsPrimary and ras keratinocytes plus TGFbeta1
We have compared the response to TGFbeta1 in normal and v-rasHa transduced primary mouse keratinocytes using NCI cDNA microarrays. This analysis reveals that Ha-ras alters global TGFbeta1 mediated gene expression in a gene specific manner. The expression pattern of TGFbeta1 immediate early response ...
ORGANISM(S): Mus musculus 
2010-06-30 | E-GEOD-3228 | biostudies-arrayexpress
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