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Maider J. Echeveste Medrano and colleagues characterized the physiological and metabolic response of freshwater methanotrophic archaea to salt stress. The study performed metaproteomics, gene expression profiles and dedicated metabolomics to identify the pathways involved in the salt stress response...
ORGANISM(S): Candidatus Methanoperedens nitroreducens 
2024-07-17 | PXD048239 | Pride
Lysosome-related organelles have versatile functions including protein and lipid degradation, signal transduction, and protein secretion. The molecular elucidation of rare congenital diseases affecting endosomal/lysosomal biogenesis has given insights into physiological functions of the innate and a...
ORGANISM(S): Homo sapiens 
Severe congenital neutropenia (CN) is a pre-leukemia syndrome that, in the majority of patients, is caused by heterogeneous ELANE mutations encoding neutrophil elastase (NE). To study leukemogenesis associated with CN we generated CN and CN/AML patient-specific induced pluripotent stem cells (iPSCs)...
ORGANISM(S): Homo sapiens 
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