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TranscriptomicsDifferential expression of snoRNAs during ATDC5 chondrogenic differentiation
Previously we have shown that the snoRNA RMRP is differentially expressed during chondrogenic differentiation and interference with its function led to important changes in the outcome of chondrogenic differentiation with consequences for ribosomal RNA levels and human disease. To identify additiona...
ORGANISM(S): Mus musculus 
2022-05-01 | E-MTAB-10529 | biostudies-arrayexpress
TranscriptomicsRNA-seq of control and CHH (cartilage-hair hypoplasia) fibroblasts transdifferentiated into chondrocytes-like cells
We used primary human CHH (cartilage-hair hypoplasia) and control fibroblasts in a chondrogenic transdifferentiation model (FDC; fibroblast-derived chondrocytes) to determine the chondrogenic capacity and differential pathway regulation of CHH cells. For the sequencing experiment, dermal fibroblasts...
ORGANISM(S): Homo sapiens 
2021-10-09 | E-MTAB-10996 | biostudies-arrayexpress
GenomicsrRNA 2'-O-methylation profile of SNORD71 knockdown cells
We generated a SNORD71 KO chondrocyte cell pool using CRISPR/Cas9 gene editing. A CRISPR control cell line was generated and used as a control. Levels of 2’-O-methylation of human rRNAs in SNORD71 KO cell pool and CRISPR control cells were evaluated by RiboMethSeq.
ORGANISM(S): Homo sapiens 
2022-03-05 | E-MTAB-11470 | biostudies-arrayexpress
TranscriptomicsRibosomal RNA 2’-O-methylation profile of human articular chondrocytes exposed to an osteoarthritic environment
We used chondrocytes exposed to osteoarthritic synovial fluid as a chronic disease model to study the effects of a chronic disease microenvironment on 2’-O-me rRNA heterogeneity. Human non-OA human articular chondrocytes (5 individual donors) were cultured either in the presence of OA-SF (20% (v/v),...
ORGANISM(S): Homo sapiens 
2022-03-05 | E-MTAB-11469 | biostudies-arrayexpress
Metabolomics1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints
Despite osteoarthritis (OA) and rheumatoid arthritis (RA) being typically age-related, their underlying etiologies are markedly different. We used 1H nuclear magnetic resonance (NMR) spectroscopy to identify differences in metabolite profiles in low volumes of OA and RA synovial fluid (SF). SF was a...
2018-10-11 | MTBLS564 | MetaboLights
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