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TranscriptomicsHuman T-ALL cell line response to inhibition of Notch signaling
Analysis of five Notch signaling-dependent human T-ALL cell lines (ALLSIL, DND41, HPBALL, KOPTK1, TALL-1) treated with gamma-secretase inhibitor (GSI) to block Notch signaling. Samples include parental cells, cells rescued by retroviral transduction with ICN (a GSI-independent form of activated Notc...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-29959 | biostudies-arrayexpress
TranscriptomicsNotch regulated miRNAs in human T-ALL cell line
In an attempt to identify miRNAs regulated by oncogenic Notch signaling, we performed miRNA profiling of human T-cell acute lymphoblastic leukemia (T-ALL) cells with or without the treatment of γ-secretase inhibitor (GSI) to block Notch signaling. We found miR-223 levels to increase after GSI treatm...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-35993 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse models with liver-specific deletion or global hypomorphic expression of the NADPH-cytochrome P450 reductase gene to study molecular mechanisms for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
NADPH-cytochrome P450 reductase (CPR) is important for the functions of many enzymes, such as microsomal cytochrome P450 (P450) monooxygenases and heme oxygenases. Two mouse models with deficient CPR expression in adults were recently generated in this laboratory: liver-Cpr-null (with liver-specific...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2362 | biostudies-arrayexpress
Genomicsmerged_dataset - samples
This dataset contains merged data from the 22 Hodgkin lymphoma and 5 reactive lymph node samples, including count data and cell cluster assignments.
EGAD00001006221 | EGA
Genomicsena-DATASET-BCCA-11-12-2019-18:47:10:446-1110 - samples
Single-cell gene expression was profiled for 22 Hodgkin lymphoma tumors and 5 reactive lymph nodes (2 replicates were performed for RLN-1). Library preparation was performed with the 10x Chromium platform (3' version 2 assay). Sequencing was performed on an Illumina NextSeq. The BAM files were gener...
EGAD00001005739 | EGA
GenomicsSingle-cell RNA sequencing of 22 Hodgkin lymphoma tumors and 5 reactive lymph nodes
Hodgkin lymphoma (HL) is characterized by an extensively dominant tumor microenvironment (TME) composed of different types of non-cancerous immune cells with rare malignant cells. Characterization of the cellular components and their spatial relationship is crucial to understanding crosstalk and the...
EGAS00001004085 | EGA
TranscriptomicsTranscription profiling of human T-ALL cell cultures treated with Compound E, a gamma-secretase inhibitor or vehicle only (DMSO) for 24 h
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T-cell development and in the pathogenesis over 50% of human T-cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcrip...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5827 | biostudies-arrayexpress
TranscriptomicsHdac6 is a stem-cell specific modulator of Tip60-p400 function (gene expression)
To identify the functional role of Hdac6 in embryonic stem cells, we examined gene expression changes in mouse ES cells upon Tip60, Hdac6 and double knockdown. Two biological replicates each for control (GFP), Tip60, Hdac6 and double KD in E14 mouse ESCs. Lentiviral-based shRNA was used and gene exp...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-42208 | biostudies-arrayexpress
UnknownA benchmark of expert-level academic questions to assess AI capabilities.
Not available
S-EPMC12851929 | biostudies-literature
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