Sort   by:  
 Page size 
TranscriptomicsGeneration and purification of Th1 and Th2 effector and memory CD4+ T cells
Naïve CD4+ T cells were isolated from spleen of AND TcR transgenic/green fluorescence protein (GFP) transgenic mice (Kaye et al., Nature 1989;341:746, Wright et al, Blood 2001;97:2278) that recognize a peptide of pigeon cytochrome C in the context of I-Ek and express CD44lo, CD62Lhi, CD45RBhi, and ...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-8352 | biostudies-arrayexpress
TranscriptomicsNotch regulated miRNAs in human T-ALL cell line
In an attempt to identify miRNAs regulated by oncogenic Notch signaling, we performed miRNA profiling of human T-cell acute lymphoblastic leukemia (T-ALL) cells with or without the treatment of γ-secretase inhibitor (GSI) to block Notch signaling. We found miR-223 levels to increase after GSI treatm...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-35993 | biostudies-arrayexpress
GenomicsWhole genome DNAse hypersensitivity in human CD4+ T-cells
Mapping DNaseI hypersensitive (HS) sites is an accurate method of identifying the location of genetic regulatory elements, including promoters, enhancers, silencers, insulators, and locus control regions. We employed whole genome tiled array strategies to identify DNaseI HS sites within human prima...
ORGANISM(S): Homo sapiens 
2007-11-19 | E-GEOD-8486 | biostudies-arrayexpress
TranscriptomicsKrüppel-like factor 4 regulates T cell function
Krüppel-like factor 4 (Klf4), a transcription factor mediating context-dependent activation or repression, plays a key role in maintaining pluripotency of stem cells and in regulating cell differentiation. However, the precise function of Klf4 in T cell development and differentiation is largely unk...
ORGANISM(S): Mus musculus 
2011-06-24 | E-GEOD-24880 | biostudies-arrayexpress
TranscriptomicsHistone methylations and gene expression in naïve, central (TCM) and effector (TEM) memory CD8 T cells.
Histone methylations play a major role in regulating the chromatin state and gene expression, yet little is known about their involvement in differential gene expression and function of memory CD8 T cells. Here, we report a genome-wide analysis of two histone H3 methylations (H3K4me3 and H3K27me3) ...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-14422 | biostudies-arrayexpress
GenomicsGenome-wide Analysis of Histone Methylations in Memory CD8+ T Cells
Histone methylations play a major role in regulating the chromatin state and gene expression, yet little is known about their involvement in differential gene expression and function of memory CD8 T cells. Here, we report a genome-wide analysis of two histone H3 methylations (H3K4me3 and H3K27me3) ...
ORGANISM(S): Homo sapiens 
2009-06-12 | E-GEOD-12616 | biostudies-arrayexpress
TranscriptomicsHuman T-ALL cell line response to inhibition of Notch signaling
Analysis of five Notch signaling-dependent human T-ALL cell lines (ALLSIL, DND41, HPBALL, KOPTK1, TALL-1) treated with gamma-secretase inhibitor (GSI) to block Notch signaling. Samples include parental cells, cells rescued by retroviral transduction with ICN (a GSI-independent form of activated Notc...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-29959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-ALL cell cultures treated with Compound E, a gamma-secretase inhibitor or vehicle only (DMSO) for 24 h
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T-cell development and in the pathogenesis over 50% of human T-cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcrip...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5827 | biostudies-arrayexpress
UnknownOptimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma.
Not available
S-EPMC5763077 | biostudies-literature
UnknownRegression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy.
Not available
S-EPMC5390684 | biostudies-literature
Sort   by:  
 Page size