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TranscriptomicsStage-specific control of early B cell development by the transcription factor Ikaros
Ikaros is an essential regulator of lymphopoiesis. Here, we studied the B-cell-specific function of Ikaros by conditional Ikzf1 inactivation in pro-B cells. B-cell development was arrested at an aberrant ‘pro-B’ cell stage characterized by increased cell adhesion and loss of pre-B cell receptor sign...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53595 | biostudies-arrayexpress
GenomicsMolecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia
PAX5 is a tumor suppressor in B-ALL, while the role of PAX5 fusion proteins in B-ALL development is largely unknown. Here we studied the function of PAX5-ETV6 and PAX5- FOXP1 in mice expressing these proteins from the Pax5 locus. Both proteins arrested Blymphopoiesis at the pro-B-to-pre-B cell trans...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-84987 | biostudies-arrayexpress
TranscriptomicsDevelopment of GRO-cap (GRO-seq followed by 5'-cap enrichment) to map transcription start sites in C. elegans
Dosage Compensation is required to correct for uneven gene dose between the sexes. We utilized global run-on sequencing (GRO-seq) to examine how Caenorhabditis elegans dosage compensation reduces transcription of X-linked genes. To facilitate these experiments, we required accurate 5M-bM-^@M-^Y-ends...
ORGANISM(S): Caenorhabditis elegans 
2013-06-18 | E-GEOD-43085 | biostudies-arrayexpress
UnknownDistinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.
Not available
S-EPMC9381462 | biostudies-literature
UnknownAbagovomab as maintenance therapy in patients with epithelial ovarian cancer: a phase III trial of the AGO OVAR, COGI, GINECO, and GEICO--the MIMOSA study.
Not available
S-EPMC5795662 | biostudies-literature
TranscriptomicsCondensin Controls Recruitment of RNA Polymerase II to Achieve X-Chromosome Dosage Compensation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Caenorhabditis elegans 
2013-06-18 | E-GEOD-43087 | biostudies-arrayexpress
MetabolomicsMetabolomic Profiling of Renal Cyst Fluid in Advanced ADPKD: Insights from Dialysis and Transplantation Cohorts

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD). While urinary metabolomics in ADPKD has been extensively studied, the composition of renal cyst fluid, par...

2025-07-07 | MTBLS12372 | MetaboLights
UnknownMeasurement of the differential cross section for top quark pair production in pp collisions at [Formula: see text].
Not available
S-EPMC4657759 | biostudies-literature
TranscriptomicsEndothelial DNA methalytion signature in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a severe and incurable pulmonary vascular disease. One of the primary origins of PAH is pulmonary endothelial dysfunction leading to vasoconstriction, aberrant angiogenesis and smooth muscle cell proliferation, endothelial-to-mesenchymal transition, thrombosi...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-84395 | biostudies-arrayexpress
UnknownSearch for supersymmetry in pp collisions at [Formula: see text] TeV in events with a single lepton, jets, and missing transverse momentum.
Not available
S-EPMC4370766 | biostudies-literature
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