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MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1223 | MetaboLights
MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Extracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1221 | MetaboLights
TranscriptomicsGene expression profiling in the liver of 3-month old mice with a mutant Wrn protein treated with vitamin C compared to the liver of 3-month old untreated mice with a mutant Wrn protein.
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase d...
ORGANISM(S): Mus musculus 
2015-05-09 | E-GEOD-68688 | biostudies-arrayexpress
ProteomicsVitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional WRN mutant protein
Werner syndrome (WS) is a premature aging disorder caused by mutations in a DNA helicase/exonuclease. Mice lacking the helicase domain of the Wrn protein orthologue exhibit transcriptomic and metabolic alterations, some of which are reversed by vitamin C. Recent studies on the liver of these animals...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-02 | PXD007758 | Pride
Mouse model Liver proteome Lc-msms shotgun Vitamin c Endoplasmic reticulum Werner syndrome Label free quantification 
TranscriptomicsTranscriptome of soleus muscle of Tenascin-C deficient 129/SV mice
1 year-old male Tenascin-C deficient 129/SV mice with the targeted insertion of a beta-lactamase cassette in the NcoI site of exon 2 of the TNC gene (Forsberg, E., Hirsch, E., Frohlich, L., Meyer, M., Ekblom, P., Aszodi, A., Werner, S. & Fassler, R. (1996) Proc. Natl. Acad. Sci U. S. A 93, 6594-6599...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8550 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild type and Wrn mutant animals with or without vitamin C treatment
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase d...
ORGANISM(S): Mus musculus 
2009-09-11 | E-GEOD-14549 | biostudies-arrayexpress
TranscriptomicsTranscriptome of reloaded soleus muscle of Tenascin-C deficient 129/SV mice
1 year-old male Tenascin-C deficient 129/SV mice with the targeted insertion of a beta-lactamase cassette in the NcoI site of exon 2 of the TNC gene (Forsberg, E., Hirsch, E., Frohlich, L., Meyer, M., Ekblom, P., Aszodi, A., Werner, S. & Fassler, R. (1996) Proc. Natl. Acad. Sci U. S. A 93, 6594-6599...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8551 | biostudies-arrayexpress
TranscriptomicsExpression profile by RNA-seq of wild type or Caenorhabditis elegans mutant for the Werner syndrome gene ortholog treated with or without vitamin C
In this study, we analyzed the impact of a mutation in the wrn-1 gene compared to wild type worms and the dietary supplementation of vitamin C on the global mRNA expression of the whole C. elegans by the RNA-seq technology. Whole C. elegans mRNA profiles at the L4 stage of wild type and wrn-1(gk99) ...
ORGANISM(S): Caenorhabditis elegans 
2014-10-07 | E-GEOD-54173 | biostudies-arrayexpress
Unknown[Werner syndrome. A prototypical form of segmental progeria.]
Not available
S-EPMC4191733 | biostudies-literature
UnknownVitamin C restores healthy aging in a mouse model for Werner syndrome.
Not available
S-EPMC3712979 | biostudies-literature
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