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TranscriptomicsGenome-wide binding of Fhl1 and Ifh1 +/- Rapamycin
Array design -Platform: amino-silane coated glass slides (GAPS II, Corning) -S. cerevisiae intergenic regions amplified from S288C genomic DNA (ResGen) using the intergenic region primer oligonucleotides (ResGen) (Harismendy et al. EMBO J. 22(18): 4738-4747, 2003). The primers allow the amplificati...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-1944 | biostudies-arrayexpress
MetabolomicsPhysiological extremes of the human blood metabolome: A metabolomics analysis of highly glycolytic, oxidative, and anabolic athletes
Human metabolism is highly variable. At one end of the spectrum, defects of enzymes, transporters, and metabolic regulation result in metabolic diseases such as diabetes mellitus or inborn errors of metabolism. At the other end of the spectrum, favorable genetics and years of training combine to res...
2022-02-07 | MTBLS2104 | MetaboLights
TranscriptomicsTranscriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer fatalities in Western societies, characterized by high metastatic potential and resistance to chemotherapy. Critical molecular mechanisms of these phenotypical features still remain unknown, thus hampering the development ...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-59761 | biostudies-arrayexpress
ProteomicsSingle-copy locus isolation identifies distinct proteomes of early- and late-firing DNA replication origin chromatin
The chromatin at origins of replication is the template for DNA replication initiation in eukaryotic genomes. However, whether the chromatin composition instructs individual origins to fire early-efficiently (EE) or late-inefficiently (LI) remains to be investigated. Here, we used site-specific reco...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-10 | PXD031984 | Pride
Replication timing Replication efficiency Affinity purification Locus-specific chromatin isolation Dna replication origin Histone ptms Site-specific recombination 
ProteomicsThe CGG triplet repeat binding protein 1 counteracts DNA secondary structure formation to prevent transcription-replication stress
Short tracts of trinucleotide repeats with less than 10 repeats are found frequently throughout the genome without any apparent negative impact on DNA replication fork progression or transcription elongation. CGG binding protein 1 (CGGBP1) binds to CGG triplet repeats and has been implicated in mult...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD045654 | Pride
Transcription-replication conflicts Genomic instability Cggbp1 R-loop structure Cgg-trinucleotide repeats Replication stress Transcription regulation Dna damag G-quadruplex structure 
ProteomicsSingle-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control
The chromatin at origins of replication is thought to influence DNA replication initiation in eukaryotic genomes. However, it remains unclear how the chromatin composition controls the firing of early-efficient (EE) or late-inefficient (LI) origins. Here, we used site-specific recombination and sing...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-16 | PXD032930 | Pride
Locus-specific chromatin isolation  site-specific recombination  affinity purification  dna replication origin  replication timing  replication efficiency  origin chromatin structure  dash complex  ask1 protein  microtubule cytoskeleton 
GenomicsGlucocorticoid receptor profiling in IMR90,K562 and U2OS (ChIP-seq)
To identify the sequences responsible for recruitment of Glucocorticoid receptor (GR) to individual loci, we performed ChIP-seq and ChIP-exo that combines chromatin immunoprecipitation with an exonuclease digestion step. We performed these experiments in three cell lines : IMR90 (ATTC:CCL-186), U2O...
ORGANISM(S): Homo sapiens 
2015-02-25 | E-MTAB-2955 | biostudies-arrayexpress
UnknownADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth
Not available
S-SCDT-10_15252-EMBJ_2022111620 | biostudies-other
UnknownInfluence of quality of intensive care on quality of life/return to work in survivors of the acute respiratory distress syndrome: prospective observational patient cohort study (DACAPO).
Not available
S-EPMC7275400 | biostudies-literature
UnknownTracheostomy in patients with acute respiratory distress syndrome is not related to quality of life, symptoms of psychiatric disorders or return-to-work: the prospective DACAPO cohort study.
Not available
S-EPMC7203349 | biostudies-literature
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