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MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Extracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1221 | MetaboLights
MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1223 | MetaboLights
TranscriptomicsGenome-wide DNA methylation profiling of Progeria and Werner syndrome patients
DNA methylation gradiently changes with age and is likely to be involved in aging-related processes resulting in phenotype changes and increased susceptibility to certain diseases. The Hutchinson-Gilford Progeria Syndrome (HGP) and Werner Syndrome are two premature aging diseases showing features of...
ORGANISM(S): Homo sapiens 
2013-01-14 | E-GEOD-42865 | biostudies-arrayexpress
GenomicNext Generation Mendelian Genetics: Atypical Werner Syndrome

Werner syndrome (WS) is an adult-onset progeroid syndrome characterized by accelerated aging. The International Registry of Werner Syndrome in the Department of Pathology, University of Washington, collects WS cases from all over the world. Classical WS is caused by WRN mutations. Those who do no...

phs000434 | dbGaP
TranscriptomicsTranscription profiling of mouse model for Werner syndrome
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. The poly(ADP-ribose) polymerase-1 (PARP-1) enzyme is also in...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3359 | biostudies-arrayexpress
GenomicsNext Generation Mendelian Genetics: Atypical Werner syndrome
Next Generation Mendelian Genetics: Atypical Werner syndrome
PRJNA80283 | ENA
GenomicsNext Generation Mendelian Genetics: Atypical Werner Syndrome

Werner syndrome (WS) is an adult-onset progeroid syndrome characterized by accelerated aging. The International Registry of Werner Syndrome in the Department of Pathology, University of Washington, collects WS cases from all over the world. Classical WS is caused by WRN mutations. Those who do no...

phs000434.v1.p1 | EGA
Unknown[Werner syndrome. A prototypical form of segmental progeria.]
Not available
S-EPMC4191733 | biostudies-literature
GenomicsWRN loss accelerates abnormal adipocyte metabolism in Werner Syndrome
WRN loss accelerates abnormal adipocyte metabolism in Werner Syndrome
PRJNA1041402 | ENA
TranscriptomicsExpression profiling of skin fibroblast and iPSC from Werner Syndrome
The premature aging disorder Werner Syndrome (WS) is characterized by early onset of aging phenotypes resembling natural aging. In most WS patients there are mutations in the DNA helicase WRN, an enzyme important in maintaining genome stability and telomere replication. Interestingly, its clinical m...
ORGANISM(S): Homo sapiens 
2013-07-11 | E-GEOD-48761 | biostudies-arrayexpress
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