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TranscriptomicsMapping of dsRNA in yeast using reconstituted RNAi pathway
Small RNA produced by Dicer (Dcr1) are used to map dsRNA in wild-type strain and a xrn1-delta mutant of S. cerevisiae, inactivated for the cytoplasmic 5'-3' RNA decay pathway. Small RNA sequencing in wild-type and xrn1-delta strains of S. cerevisiae, with or without reconstituted RNAi pathway.
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-11 | E-GEOD-64090 | biostudies-arrayexpress
TranscriptomicsRNA processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.
Eukaryotic cells respond to DNA double-strand breaks (DSBs) by activating a checkpoint that depends on the protein kinases Tel1/ATM and Mec1/ATR. Mec1/ATR is activated by RPA-coated single-stranded DNA (ssDNA), which arises upon nucleolytic degradation (resection) of the DSB. Emerging evidences indi...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-20 | E-GEOD-63444 | biostudies-arrayexpress
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