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ProteomicsPhosphoproteomics measurement of clonal endocrine therapy sensitive and resistant breast cancer populations
Around two thirds of breast tumors are characterized by the expression of estrogen receptor α and are therapeutically treated by blocking estrogen signaling. First line endocrine therapeutics are Tamoxifen which displaces estrogen form its receptor preventing receptor activation and aromatase inhibi...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040478 | Pride
Phosphoproteomics Clonal deconvolution Breast cancer Therapy resistance 
ProteomicsPAK1 activation as a common mechanism of endocrine therapy resistance in luminal A breast cancer models
Breast cancer is a highly heterogeneous disease, representing the most frequent malignancy and the second leading cause of cancer-related mortality in women worldwide. Among breast cancer subtypes, estrogen receptor-positive (ER+) tumors are often treated with endocrine therapies such as Tamoxifen o...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD063393 | Pride
Endocrine therapy Breast cancer Therapy resistance Phosphoproteomics 
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