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GenomicGlaucoma Exome Sequencing

This is a study of primary open angle glaucoma (POAG) conducted through exome sequencing of cases and comparison of variant frequencies with general population frequencies available in dbGAP and controlled for sequencing platform artifact to minimize false positives.

POAG is an intraocular...

phs000558 | dbGaP
GenomicNEIGHBOR Consortium Glaucoma GWAS

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238 | dbGaP
TranscriptomicsPrimary mouse myeloid dendritic cell transcriptome response to a wild type infectious clone of West Nile virus (WNVMT) and mutant virus (WNVE218A).
The purpose is to obtain samples for mRNA analysis in primary mouse myeloid dendritic cells infected with wild type West Nile virus (WNVMT) and mutant virus (WNVE218A). Mouse (C57Bl/6J) primary myeloid dendritic cells (D10 after seeding of leukocytes from bone marrow) were seeded at 2 x 10^5 cells p...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-75222 | biostudies-arrayexpress
TranscriptomicsMouse primary myeloid dendritic cell transcriptome response to a wild type infectious clone of West Nile virus (WNVMT) and mutant virus (WNVE218A).
The purpose is to obtain samples for mRNA analysis in primary mouse myeloid dendritic cells infected with wild type West Nile virus (WNVMT) and mutant virus (WNVE218A). Mouse (C57Bl/6J) primary amyeloid dendritic cells (D10 after seeding of leukocytes from bone marrow) were seeded at 2 x 10^5 cells ...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74628 | biostudies-arrayexpress
TranscriptomicsIRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
Myeloid dendritic cells from WT, Irf3-/-xIrf7-/-, Irf3-/-xIrf5-/-xIrf7-/-, Mavs-/- (IPS1-/-)and Ifnar-/- mice were infected with West Nile virus to assess the contributions of specific signaling and transcription factors in initiating the antiviral response RPMI + rmGM-CSF purified bone marrow deriv...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-41355 | biostudies-arrayexpress
UnknownAnalyzing Variability in Ebola-Related Controls Applied to Returned Travelers in the United States.
Not available
S-EPMC4582682 | biostudies-literature
UnknownInhibition or genetic reduction of ASAH1/acid ceramidase restore α-synuclein clearance in mutant GBA1 dopamine neurons from Parkinson's patients.
Not available
S-EPMC12680604 | biostudies-literature
UnknownDiscovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.
Not available
S-EPMC4025788 | biostudies-literature
GenomicsThe long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites
Long noncoding RNAs (lncRNAs) are important regulators of chromatin; however, the mechanistic roles for many lncRNAs are poorly understood in part because their direct interactions with genomic loci and proteins are difficult to assess. We used CHART-seq to map the genomic binding sites for two high...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-58444 | biostudies-arrayexpress
TranscriptomicsTopoisomerase I cleavage complexes preferentially down-regulate ubiquitin- and RNA degradation-related transcripts in relationship to gene length, exon-intron junctions and p53-dependent up-regulation of miR-142-3p
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-04-17 | E-GEOD-37358 | biostudies-arrayexpress
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