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TranscriptomicsInterferon lambda restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier
Although type III interferons (IFN), also known as IFN-λ or IL28/IL-29, restrict infection by several viruses, their mechanism of inhibitory action has remained uncertain. We used recombinant IFN-λ and mice lacking the IFN-λ receptor (IFNLR1) to evaluate the effect of IFN-λ on infection with West Ni...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64735 | biostudies-arrayexpress
TranscriptomicsA Mouse Model of Chronic West Nile Virus Infection
Here, we characterize the RIX line CC(032x013)F1, which serves as a mouse model of chronic WNV infection. While studies using C57BL/6 mice have shown that WNV RNA can persist in the CNS up to 3 months post infection in a limited fraction of mice (Appler et al., 2010), to date there is a lack of a ro...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-82046 | biostudies-arrayexpress
TranscriptomicsPrimary mouse myeloid dendritic cell transcriptome response to a wild type infectious clone of West Nile virus (WNVMT) and mutant virus (WNVE218A).
The purpose is to obtain samples for mRNA analysis in primary mouse myeloid dendritic cells infected with wild type West Nile virus (WNVMT) and mutant virus (WNVE218A). Mouse (C57Bl/6J) primary myeloid dendritic cells (D10 after seeding of leukocytes from bone marrow) were seeded at 2 x 10^5 cells p...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-75222 | biostudies-arrayexpress
TranscriptomicsMouse primary myeloid dendritic cell transcriptome response to a wild type infectious clone of West Nile virus (WNVMT) and mutant virus (WNVE218A).
The purpose is to obtain samples for mRNA analysis in primary mouse myeloid dendritic cells infected with wild type West Nile virus (WNVMT) and mutant virus (WNVE218A). Mouse (C57Bl/6J) primary amyeloid dendritic cells (D10 after seeding of leukocytes from bone marrow) were seeded at 2 x 10^5 cells ...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74628 | biostudies-arrayexpress
ProteomicsRNA to rule them all: Critical steps in Lassa virus ribonucleoparticle assembly and recruitment
Lassa virus is a negative-strand RNA virus with only four structural proteins that causes periodic outbreaks in West Africa. The nucleoprotein (NP) encapsidates the viral genome, forming the ribonucleoparticles together with the viral RNA and the L protein, which have to be continuously restructured...
ORGANISM(S): Lassa mammarenavirus 
2023-12-18 | PXD040186 | Pride
Native ms Lassa virus 
TranscriptomicsDevelopment of distinct gene expression signature in neurons from different regions of the brain
We have performed microarray expression profiling of mouse primary neurons (cortical neurons and granule cell neurons) to model molecular networks and define whether distinct antiviral IFN responses occurred in neurons corresponding to different brain regions. Primary mouse cortical neurons and gran...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-42727 | biostudies-arrayexpress
TranscriptomicsDownregulation of integrin receptor signalling genes by EBV EBNA 3C
Comparsion of cellular gene expression between a control B lymphoma cell-line (BJAB pz2) stably transfected with an empty vector and a BJAB cell-line stably expressing Epstein-Barr virus EBNA 3C (BJAB E3C-4). These cell lines are described in Wang, F., C. Gregory, C. Sample, M. Rowe, D. Liebowitz, R...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-MEXP-3585 | biostudies-arrayexpress
TranscriptomicsIRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
Myeloid dendritic cells from WT, Irf3-/-xIrf7-/-, Irf3-/-xIrf5-/-xIrf7-/-, Mavs-/- (IPS1-/-)and Ifnar-/- mice were infected with West Nile virus to assess the contributions of specific signaling and transcription factors in initiating the antiviral response RPMI + rmGM-CSF purified bone marrow deriv...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-41355 | biostudies-arrayexpress
TranscriptomicsCytokine stimulation systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
Background: The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic potential of coronaviruses and the severe disease these etiologic agents can cause in humans. Clinical features of Middle East respiratory syndrome (MERS) include severe acu...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56677 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of Calu-3 2B-4 cells stimulated with Interleukin-1a and TNFa.
Calu-3 2B-4 cells were stimulated with interleukin-1a or TNFa. Transcriptional analysis of the extracted RNA was done by microarray. Calu-3 2B-4 cells were washed with phosphate-buffered saline (PBS) and treated with either IL-1a (0.001ng/ml) or TNFa (0.05ng/ml) or mock diluted in PBS for 40 min at...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56678 | biostudies-arrayexpress
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