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MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
TranscriptomicsA sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzyma...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-34055 | biostudies-arrayexpress
TranscriptomicsOncogenic MYC induces a dependency on the spliceosome in human cancer
c-MYC (MYC) overexpression or hyperactivation is one of the most common drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to therapeutic inhibition. Like other classic oncogenes, hyperactivation of MYC leads to collateral stresses onto cancer cells, suggesting t...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-66182 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human eessential thrombocythemia megakaryocytes versus normal megakaryocytes
Normal donors BM CD34+ cells were differentiated in thrombopoietin-treated liquid suspension cultures. Briefly, CD34+ cells (80,000 /mL) were resuspended in a serum-free medium in the presence of 100 ng/mL of human recombinant thrombopoietin (TPO; Genzyme, Boston, MA). Every 3 days, viable cells wer...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-997 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human essential Thrombocythemia (ET) vs normal (baseline) megakaryocytes
Essential Thrombocythemia (ET) patients, as well as normal donors BM CD34+ cells were differentiated in thrombopoietin-treated liquid suspension cultures. Briefly, CD34+ cells (80,000 /mL) were resuspended in a serum-free medium in the presence of 100 ng/mL of human recombinant thrombopoietin (TPO; ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-567 | biostudies-arrayexpress
UnknownSMA Identified: Clinical and Molecular Findings From a Sponsored Testing Program for Spinal Muscular Atrophy in More Than 2,000 Individuals.
Not available
S-EPMC8134668 | biostudies-literature
UnknownDissemination of the Results of Pediatric Clinical Trials Funded by the US National Institutes of Health.
Not available
S-EPMC9945062 | biostudies-literature
UnknownComparison of EMG power during sleep from the submental and frontalis muscles.
Not available
S-EPMC6287659 | biostudies-literature
TranscriptomicsTranscriptional profiling of whole-blood in Mycobacterium avium subsp. paratuberculosis-infected cattle
To provide novel insights into understanding the host-immune response during the different stages of progression of the disease, we performed gene expression profiling in Mycobacterium avium subsp. paratuberculosis infection in cattle. We analyzed the transcriptional profiles of whole-blood cells of...
ORGANISM(S): Bos taurus 
2014-10-31 | E-GEOD-62835 | biostudies-arrayexpress
UnknownSerological and molecular prevalence of canine vector-borne diseases (CVBDs) in Korea.
Not available
S-EPMC5353868 | biostudies-literature
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