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TranscriptomicsResponse of peripheral blood mononuclear cells to west nile virus (E, NS2a) and type 1 diabetogenic antigens (GAD65, ZnT8) derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 3 healthy donors. The cells ...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72372 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing of human immune cell subsets across diseases
This study compared whole transcriptome signatures of 6 immune cell subsets and whole blood from patients with an array of immune-associated diseases. Fresh blood samples were collected from healthy subjects and subjects diagnosed type 1 diabetes, amyotrophic lateral sclerosis, and sepsis, as well a...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-60424 | biostudies-arrayexpress
TranscriptomicsA Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients' Plasma (PBMC)
The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on ...
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-49754 | biostudies-arrayexpress
TranscriptomicsA Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients' Plasma (DC)
The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on ...
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-49753 | biostudies-arrayexpress
TranscriptomicsA Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients' Plasma (Neutrophil)
The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on ...
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-49755 | biostudies-arrayexpress
TranscriptomicsA Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients' Plasma (Expt. 2)
The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on ...
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-49756 | biostudies-arrayexpress
TranscriptomicsDysregulated TLR7 signaling drives anemia via development of hemophagocytic macrophages
The debilitating autoimmune disease Systemic Lupus Erythematosus (SLE) is closely associated with Toll-like receptor (TLR) 7 and type I interferon (IFN) activity in humans and in murine SLE-like disease. Two central manifestations of SLE affect the myeloid lineage of the immune system, myeloid expan...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-70520 | biostudies-arrayexpress
TranscriptomicsResponse of peripheral blood mononuclear cells from 20 healthy donor and 15 patients with type 1 diabetes to type 1 diabetogenic protein (IGRP, PPI) derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 20 healthy donors and 15 pat...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72377 | biostudies-arrayexpress
TranscriptomicsResponse of peripheral blood mononuclear cells to influenza virus, human cytomegalovirus, and candida albicans derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 1 healthy donor. The cells w...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72371 | biostudies-arrayexpress
TranscriptomicsResponse of peripheral blood mononuclear cells from 15 healthy donor and 15 patients with type 1 diabetes to type 1 diabetogenic protein (GAD65, IGRP, PPI, ZnT8) and influenza virus M derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 15 healthy donors and 15 pat...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72376 | biostudies-arrayexpress
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