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TranscriptomicsHigh conservation in transcriptomic and proteomic response of white sturgeon to equipotent concentrations of 2,3,7,8-TCDD, PCB 77, and benzo[a]pyrene
Adverse effects associated with exposure to dioxin-like compounds (DLCs) are mediated primarily through activation of the aryl hydrocarbon receptor (AHR). However, little is known about the cascades of events that link activation of the AHR to apical adverse effects. Therefore, this study used high-...
ORGANISM(S): Acipenser transmontanus 
2016-09-01 | E-GEOD-79624 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of white blood cells from human males before and after exercise to determine the effect of acute exercise on gene expression profiles inwhite blood cells and to identify genes for use as markers for monitoring exercise and training load
White blood cells (WBCs) express tens of thousands of genes. Their expression levels are modified by genetic and external factors. The purpose of the present study was to investigate the effects of acute exercise on gene expression profiles (GEPs) of WBCs and to identify suitable genes which may ser...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3606 | biostudies-arrayexpress
TranscriptomicsPig Longissimus muscle in Basque and Large White pigs reared in 3 different rearing systems
Transcriptional profiling of pig skeletal muscle in 2 breeds [(Large white , LW, conventional) and (Basque, B, local, indigeneous)] and 3 rearing systems [(Conventional, C), (Alternative, A) and (Extensive, E)]. 5 groups (BC,BA,BE,LWC and LWA) of 10 samples (i.e. biological replicates). One replica...
ORGANISM(S): Sus scrofa 
2013-01-10 | E-GEOD-33958 | biostudies-arrayexpress
TranscriptomicsPredicting the efficacy of anthracyclines in breast cancer (BC) patients: The results of the TOP trial
PURPOSE: Validated biomarkers predictive of response/resistance to anthracyclines in breast cancer are currently lacking. The neoadjuvant TOP trial, in which patients with estrogen receptor (ER)-negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to ev...
ORGANISM(S): Homo sapiens 
2010-01-26 | E-GEOD-16446 | biostudies-arrayexpress
TranscriptomicsGenomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome
Blood genomic profiling has been applied to disorders of the blood and various organ systems including brain to elucidate disease mechanisms and identify surrogate disease markers. Since most studies have not examined specific cell types, we performed a preliminary genomic survey of major blood cell...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-72642 | biostudies-arrayexpress
TranscriptomicsGlobal insights into high temperature and drought stress regulated genes by RNA-Seq in economically important oilseed crop Brassica juncea
Purpose: Brassica. juncea is vulnerable to abiotic stresses at specific stages in its life cycle. However, till date no attempts have been made to elucidate the genome-wide changes in the transcriptome of B. juncea subjected to either high temperature or drought stress. Hence, to gain global insigh...
ORGANISM(S): Brassica juncea 
2015-08-28 | E-GEOD-64242 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Affymetrix]
In addition to gaining knowledge on in vivo miRNA responses to formaldehyde, we set out to relate these miRNA responses to transcriptional profiles modified by formaldehyde. Rats were exposed by inhalation to either 0 or 2 ppm formaldehyde (6 hours/day) for 28 days. Genome-wide transcriptional profi...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42394 | biostudies-arrayexpress
TranscriptomicsLong RNAs expression profiling of 20 Italian Large White pig backfat
We report the application of Illumina RNA sequencing for characterization and discovery of genes and transcripts in Italian Large Whtie pig backfat tissue. RNAs sequencing for long RNA quantification, discovery, characterisation and differential expression evaluation.
ORGANISM(S): Sus scrofa 
2016-03-15 | E-GEOD-68007 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain from mice with multiple sclerosis, Alzheimers disease and permanent mid-cerebral artery occlusion from stroke to compare of gene expression changes characterizing these three different central nervous system pathologies
Three mouse models of human central nervous system pathologies were selected for analyzing gene expression changes compared to wild type normal brain. The selected models are: TgAPP23 for Alzheimerï¾’s disease (see Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.H., Mistl, C., Rothac...
ORGANISM(S): Mus musculus 
2008-07-12 | E-MTAB-1 | biostudies-arrayexpress
TranscriptomicsIdentification of pro-fibrotic macrophages populations by scRNA-seq in West Highland white terriers affected with canine idiopathic pulmonary fibrosis
We used the scRNA-seq to characterize disease-related heterogeneity within cell populations of macrophages/monocytes in the bronchoalveolar lavage fluid from West Highland white terriers either healthy or affected with canine idioapthic pulmonary fibrosis. The disease is still not well understood, o...
ORGANISM(S): Canis lupus familiaris 
2020-12-02 | E-MTAB-9623 | biostudies-arrayexpress
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