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TranscriptomicsMolecular responses to prolonged darkness and subsequent acclimation to re-illumination in the diatom Phaeodactylum tricornutum
We have investigated both the response to prolonged darkness and the re-acclimation to M-bM-^@M-^\moderate intensityM-bM-^@M-^] white irradiance (E = 100 M-BM-5mol m-2 s-1) in the diatom Phaeodactylum tricornutum, using an integrated approach involving global transcriptional profiling, pigment analy...
ORGANISM(S): Phaeodactylum tricornutum 
2013-04-01 | E-GEOD-42039 | biostudies-arrayexpress
TranscriptomicsSystem responses to equal doses of photosynthetically usable radiation of blue, green, and red light in the marine diatom Phaeodactylum tricornutum.
We have studied the transcriptional, metabolic and photo-physiological responses to light of different spectral quality in the marine diatom Phaeodactylum tricornutum through time-series studies of cultures exposed to equal doses of photosynthetically usable radiation of blue, green and red light. T...
ORGANISM(S): Phaeodactylum tricornutum 
2014-12-22 | E-GEOD-55959 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of responses to cadmium in the diatom Phaeodactylum tricornutum
The only group of organisms in which a biological function for cadmium has been shown is the diatoms, which are unicellular phytoplankton. Yet diatoms exhibit similar sensitivity to Cd as other groups of phytoplankton. We have investigated responses of Cd on molecular, metabolic and physiological le...
ORGANISM(S): Phaeodactylum tricornutum 
2011-08-01 | E-GEOD-31131 | biostudies-arrayexpress
TranscriptomicsR. sphaeroides delta-cryB vs. R. sphaeroides 2.4.1 photo-oxidative stress, aerobic conditions
Transcriptional profiling of R. sphaeroides delta-cryB compared to control R. sphaeroides 2.4.1 under photo-oxidative stress, aerobic conditions. Two-strain experiment under 20' photo-oxidative stress (singlet oxygen generated by methylene blue under high light illumination) and aerobic (180 µM) con...
ORGANISM(S): Rhodobacter sphaeroides 2.4.1 
2011-11-09 | E-GEOD-33553 | biostudies-arrayexpress
TranscriptomicsAn Integrated Analysis of Molecular Acclimation to High Light in the Marine Diatom Phaeodactylum tricornutum
Photosynthetic diatoms are exposed to rapid and unpredictable changes in irradiance and spectral quality, and must be able to adapt their light harvesting systems to varying light conditions. Molecular mechanisms behind light acclimation in diatoms are largely unknown. We set out to investigate the ...
ORGANISM(S): Phaeodactylum tricornutum 
2009-11-05 | E-GEOD-17237 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in intestinal mouse crypts after loss of KLF5
To determine potential targets of KLF5 we performed RNA-sequencing on jejunal crypts isolated from Klf5-deficient and wildtype mice, using three biological replicates per genotype. We identified 1,480 genes that showed significant differential expression with at least a 2-fold difference between Kl...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-79758 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human immature dendritic cells co-cultivated with Aspergillus fumigatus, Candida albicans and LPS
In a whole-transcriptome study, cellular responses of DCs confronted with the fungi A. fumigatus, C. albicans or the bacterial cell wall component LPS were investigated. Therefore DCs of four independent donors were harvested after 6 and 12 hours co-culture with A. fumigatus, C. albicans and LPS and...
ORGANISM(S): Homo sapiens 
2015-06-23 | E-GEOD-69723 | biostudies-arrayexpress
TranscriptomicsWhy does HAMLET preferentially kill tumor cells? p38-dependent death in tumor but up-regulation of innate immunity in healthy, differentiated cells
HAMLET triggers a p38- and ER stress-dependent death response in carcinoma cells. Transcriptome and proteome analysis detected an increase in p38 expression and phosphorylation exclusively in carcinoma cells and p38 inhibitors delayed the death response to HAMLET in carcinoma and lymphoma cells. ER...
ORGANISM(S): Homo sapiens 
2010-08-24 | E-GEOD-23772 | biostudies-arrayexpress
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