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TranscriptomicsImpact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-l-galactose phosphorylase
The l-galactose (Smirnoff-Wheeler) pathway represents the major route to l-ascorbic acid (vitamin C) biosynthesis in plants. Arabidopsis thaliana VTC2 and its paralogue VTC5 function as GDP-l-galactose phosphorylases converting GDP-l-galactose to l-galactose-1-P, thus catalyzing the first committed ...
ORGANISM(S): Chlamydomonas reinhardtii 
2012-05-02 | E-GEOD-34826 | biostudies-arrayexpress
TranscriptomicsOrigin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp - single cell RNAseq dataset 1
Splenic white pulp (WP) structures are underpinned by fibroblastic stromal cells (FSCs) to facilitate splenic compartmentalization and execute efficient immune responses. Although distinct WP FSCs exhibit various molecular traits, the origin and the hierarchical differentiation of different cell sub...
ORGANISM(S): Mus musculus 
2019-03-27 | E-MTAB-7094 | biostudies-arrayexpress
GenomicsEffect of LINC00899 depletion on histone mark enrichment in HeLa cells
LncRNAs represent a major transcriptional output of the human genome, but the function of many of these elements is unknown. In this experiment, we have used the ‘CUT&RUN’ technique to quantify the changes in histone mark enrichment across the genome upon depletion of the lncRNA LINC00899 in HeLa ce...
ORGANISM(S): Homo sapiens 
2019-03-29 | E-MTAB-7419 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of white adipose tissue in five week old Insulin Receptor Substrate-2 (IRS-2) mice
Mice which lack IRS-2, develop insulin resistance. Comparison between white adipose tissue from 5 week old IRS-2 KO and wild type mice. Processed data is not included for this experiment and therefore these data are not MIAME compliant
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-1 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of white adipose tissue in eight week old Insulin Receptor Substrate-2 (IRS-2) knock out mice
Mice which lack IRS-2, develop insulin resistance. Comparison between white adipose tissue from 8 week old IRS-2 KO and wild type mice. Processed data is not included for this experiment and therefore these data are not MIAME compliant
ORGANISM(S): Mus musculus 
2012-01-01 | E-BAIR-2 | biostudies-arrayexpress
GenomicsCTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-06-27 | E-GEOD-67893 | biostudies-arrayexpress
GenomicsVitamin C induces Tet-dependent DNA demethylation in ES cells to promote a blastocyst-like methylome [MeDIP-Seq]
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germline and may be mediated by Tet (ten-eleven-translocation) enzymes, which convert 5-methylcytosine (...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-46402 | biostudies-arrayexpress
TranscriptomicsFibroblastic reticular cells in the spleen - total splenic Stroma cells - single cell RNAseq dataset 2
Splenic white pulp (WP) structures are underpinned by fibroblastic stromal cells (FSCs) to facilitate splenic compartmentalization and execute efficient immune responses. Although distinct WP FSCs exhibit various molecular traits, the origin and the hierarchical differentiation of different cell sub...
ORGANISM(S): Mus musculus 
2019-03-27 | E-MTAB-7703 | biostudies-arrayexpress
TranscriptomicsR13_1-6_eve-GFP
modENCODE_submission_2603 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of all the Transcription Factors (TF) and DNA associated proteins on the genom...
ORGANISM(S): Drosophila melanogaster 
2011-03-30 | E-GEOD-26221 | biostudies-arrayexpress
TranscriptomicsISO1_8-16_mod_mdg4
modENCODE_submission_2602 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of all the Transcription Factors (TF) and DNA associated proteins on the genom...
ORGANISM(S): Drosophila melanogaster 
2011-03-30 | E-GEOD-26220 | biostudies-arrayexpress
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