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TranscriptomicsTypes I GT1, II Me49, III CTGara strains - tachyzoite and Compound 1
Previous studies suggested that specific bradyzoite genes were differentially expressed in the three major lineages common to North America and Europe (Radke et al., 2006). In order to determine if these differences extended to the global transcriptome, we characterized whole-cell mRNA levels in bot...
ORGANISM(S): Toxoplasma gondii 
2010-05-19 | E-GEOD-16037 | biostudies-arrayexpress
TranscriptomicsCell cycle-dependent, intercellular transmission of Toxoplasma gondii is accompanied by marked changes in parasite gene expression.
Intracellular microbes have evolved efficient strategies for transitioning from one cell to another in a process termed intercellular transmission. Here we show that host cell transmission of the obligate intracellular parasite Toxoplasma gondii is closely tied to specific cell cycle distributions, ...
ORGANISM(S): Toxoplasma gondii 
2010-12-27 | E-GEOD-20480 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression differences between GT1, RH-ERP2009 and RH-JSR
Previous studies have shown that continuous in vitro passage can result in changes to the global gene expression profiles in mammalian cells. To examine the extent of gene expression differences between highly homologous type I strains, we took advantage of the T. gondii Affymetrix microarray conta...
ORGANISM(S): Toxoplasma gondii 
2010-06-20 | E-GEOD-16115 | biostudies-arrayexpress
ProteomicsBeta-cell Galphas signaling is critical for physiological and pharmacological enhancement of insulin secretion
Islet lysates were adjusted to 5 percent SDS in TEAB, pH 8.5, reduced and alkylated and digested with modified trypsin (Worthington) using an S-trap mini device (Protifi). Peptides were labeled with TMT16 reagents (lot ZH350094). Phosphopeptide enrichment used GL Sciences p10 TiO tips. LC-MS/MS used...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-05-13 | MSV000097882 | MassIVE
GenomicsNational Heart, Lung, and Blood Institute (NHLBI) Bench to Bassinet Program: The Pediatric Cardiac Genetics Consortium (PCGC)

Multi-center, prospective observational cohort study of individuals with congenital heart defects (CHD). Phenotypic data and source DNA of probands, parents, and families of interest are being collected to investigate relationships between genetic factors and phenotypic and clinical outcomes in p...

phs000571.v1.p1 | EGA
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
TranscriptomicsRNA-seq comparison of fetal lung and cultured fetal lung derived organoids with pluripotent stem cell derived lung organoids
Underdeveloped lungs are the primary cause of death in premature infants, however, little is known about stem and progenitor cell maintenance during human lung development. In this study, we have identified that FGF7, Retinoic Acid and CHIR-99021, a small molecule that inhibits GSK3 to activate Wnt ...
ORGANISM(S): Homo sapiens 
2018-11-17 | E-MTAB-6023 | biostudies-arrayexpress
UnknownLifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.
Not available
S-EPMC10165492 | biostudies-literature
UnknownCommon Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.
Not available
S-EPMC4474865 | biostudies-literature
UnknownEvaluating the Appropriate Use Criteria for Coronary Revascularization in Stable Ischemic Heart Disease Using Randomized Data From the ISCHEMIA Trial.
Not available
S-EPMC11919559 | biostudies-literature
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