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To explore the role of miR-22 targeting in different tissues in adult mice, we generated a miR-22 null mouse model and profiled expression in muscle, heart, liver, kidney and white adipose tissue.
ORGANISM(S): Mus musculus 
Insulin acts on adipocytes to control whole-body glucose and lipid metabolism by increasing glucose uptake and inhibiting lipolysis. These processes are dependent on changes in protein localisation (e.g GLUT4 translocation to the plasma membrane (PM)). However, our knowledge of spatial proteomic cha...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-06 | PXD061017 | Pride
A chemical screen was performed in search of compounds that modify plant responses to sucrose. This screen uncovered that sulfamethoxazole (SMX), a folate biosynthesis inhibitor, acted synergistically with sucrose to inhibit hypocotyl elongation, suggesting interaction between these two pathways. Tr...
ORGANISM(S): Arabidopsis thaliana 
Trichomes are specialised epidermal cells that generally play a role in reducing transpiration and act as a deterrent to herbivory. In a screen of activation tagged Populus tremula x P. alba 717-1B4 trees, we identified a mutant line, fuzzy, with increased foliar trichome density. This mutant also h...
ORGANISM(S): Populus tremula x Populus alba 
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. Using a pancreatic cancer mouse model, we applied a microfluidic device to isolate CTCs independently of tumor epitopes, subjecting these to single cell RN...
ORGANISM(S): Mus musculus 
Investigation of the gene expression changes associated with TLR2 adjuvant (lipoteichoic acid; LTA) inhibition of allergic TH2 responses in peripheral blood mononuclear cell cultures (derived from house dust mite allergic individuals) stimulated with house dust mite extract. Pooled samples from 5 in...
ORGANISM(S): Homo sapiens 
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