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MetabolomicsIncreased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke
The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. To achieve this goal, we compared the brain metabolomes of ipsilateral and contralateral hemispheres from aged male mice u...
2022-10-06 | MTBLS5543 | MetaboLights
TranscriptomicsStereo-seq analysis of human multiple sclerosis white matter lesions
Fresh frozen samples from human white matter MS lesions. Using Stereo-seq we compared mixed active/inactive lesions with lipid-laden foamy microglia with lesions containing ramified microglia. Study includes post-mortem subcortical white matter (WM) tissue of n = 7 donors with MS (5 females, 2 male...
ORGANISM(S): Homo sapiens 
2026-05-11 | E-MTAB-17040 | biostudies-arrayexpress
ProteomicsComparative proteomic profiling identifies reciprocal expression of mitochondrial proteins between white and grey matter lesions from multiple sclerosis brains
Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS), where ongoing demyelination and remyelination failure are the major factors for progressive neurological disability. In this report, we employed a comprehensive proteomic approach and imm...
ORGANISM(S): Homo sapiens (Human) 
2021-12-21 | PXD029285 | Pride
Multiple sclerosis Mass spectrometry Gray matter lesion White matter lesion Mitochondria 
GenomicsLesion-remote astrocytes govern microglia-mediated white matter repair III
Lesion-remote astrocytes govern microglia-mediated white matter repair III
PRJNA1377547 | ENA
GenomicsLesion-remote astrocytes govern microglia-mediated white matter repair
Lesion-remote astrocytes govern microglia-mediated white matter repair
PRJNA1377587 | ENA
GenomicsFocal white matter lesions drive grey matter inflammation, neuronal dysfunction and synapse loss
Focal white matter lesions drive grey matter inflammation, neuronal dysfunction and synapse loss
PRJNA1370900 | ENA
TranscriptomicsFocal white matter lesions drive grey matter inflammation, neuronal dysfunction and synapse loss
Focal white matter lesions occur in most neurodegenerative disorders. Despite occurring early in disease, white matter lesions are considered either independent of, or secondary to, grey matter neuroinflammation, synapse loss and altered neuronal activity. Notably their functional impact on neuronal...
ORGANISM(S): Rattus norvegicus 
2026-02-05 | GSE311781 | GEO
GenomicsLesion-remote astrocytes govern microglia-mediated white matter repair II
Lesion-remote astrocytes govern microglia-mediated white matter repair II
PRJNA1377544 | ENA
GenomicsLesion-remote astrocytes govern microglia-mediated white matter repair IV
Lesion-remote astrocytes govern microglia-mediated white matter repair IV
PRJNA1377593 | ENA
GenomicsLesion-remote astrocytes govern microglia-mediated white matter repair I
Lesion-remote astrocytes govern microglia-mediated white matter repair I
PRJNA1377527 | ENA
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