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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsNrf2b: a novel zebrafish paralog of the oxidant-responsive transcription factor Nrf2.
We identified a novel paralog of the antioxidant response element transcription factor, Nrf2 in zebrafish. To determine whether the paralogs Nrf2a and Nrf2b regulate different sets of genes, we performed loss-of-function experiments followed by microarray-based gene expression profiling, performed ...
ORGANISM(S): Danio rerio 
2011-12-20 | E-GEOD-32594 | biostudies-arrayexpress
TranscriptomicsCommon mechanism underlies repeated evolution of extreme pollution tolerance
This is a common-garden experiment comparing the transcriptional response to multiple doses of PCB-126 among multiple populations of the killifish Fundulus heteroclitus
ORGANISM(S): Fundulus heteroclitus 
2011-01-15 | E-MTAB-496 | biostudies-arrayexpress
TranscriptomicsF. heteroclitus 3 Chesapeake population hypoosmotic challenge
This is a common-garden experiment comparing the transcriptional response to hypo-osmotic acclimation among multiple populations of the killifish Fundulus heteroclitus. Original data are in the archive: E-MTAB-524.additional.zip
ORGANISM(S): Fundulus heteroclitus 
2011-02-07 | E-MTAB-524 | biostudies-arrayexpress
TranscriptomicsFundulus majalis-heteroclitus osmotic response
The goals of these studies are to explore the mechanisms that enable extreme physiological plasticity and that may account for evolutionary divergence of adaptive osmotic physiologies among taxa that occupy different osmotic niches. In a common-garden environment, we track physiological and genome ...
ORGANISM(S): Fundulus majalis 
2013-04-23 | E-MTAB-1551 | biostudies-arrayexpress
TranscriptomicsBP oil spill field study 2010
BP oil spill field study 2010
ORGANISM(S): Fundulus heteroclitus 
2011-10-20 | E-MTAB-663 | biostudies-arrayexpress
TranscriptomicsBP oil spill - lab - gill
In this study we characterize the gill transcriptome changes in Gulf killifish (Fundulus grandis) that coincide with controlled laboratory-based exposure to various concentrations of experimentally-weathered south Louisiana crude oil. Gill transcription was contrasted between doses and across timep...
ORGANISM(S): Fundulus grandis 
2014-08-11 | E-MTAB-2834 | biostudies-arrayexpress
TranscriptomicsLucania parva-goodei osmotic response
The goals of these studies are to explore the mechanisms that may account for evolutionary divergence of adaptive osmotic physiologies among taxa that occupy different osmotic niches. In a common-garden environment, we track genome expression responses to hyper-osmotic (brackish water) challenge du...
ORGANISM(S): Lucania goodei 
2013-09-06 | E-MTAB-1854 | biostudies-arrayexpress
TranscriptomicsBP oil spill - field - gill
In this study we characterize the gill transcriptome changes that coincide with the arrival of contaminating oil in field-collected Gulf killifish Fundulus grandis. Gill transcription was contrasted before and after the arrival of oil, and between oil impacted and reference sites. Animals were sam...
ORGANISM(S): Fundulus grandis 
2013-04-18 | E-MTAB-1622 | biostudies-arrayexpress
TranscriptomicsBP oil spill - lab - liver
In this study we characterize the liver transcriptome changes in Gulf killifish (Fundulus grandis) that coincide with controlled laboratory-based exposure to various concentrations of experimentally-weathered south Louisiana crude oil. Liver transcription was contrasted between doses and across tim...
ORGANISM(S): Fundulus grandis 
2014-08-13 | E-MTAB-2841 | biostudies-arrayexpress
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