Sort   by:  
 Page size 
ProteomicsExtracellular Matrix Signatures of Human Primary Metastatic Colon Cancers and their Liver Metastases
Naba A, Clauser KR, Whittaker CA,Carr SA, Tanabe KK, Hynes RO. 2014
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-02-20 | MSV000078555 | MassIVE
TranscriptomicsMYB silencing in CD34+ progenitor cells
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb in human hematopoietic lineage commitment, we studied the effects of its silencing during the commitment of human CD34+ Hematopoietic stem/progeni...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-13110 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD14-myeloblasts
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb during the terminal differentiation of hematopoietic precursors, we studied the effects of its silencing in human primary CD14-myeloblasts, which ...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21943 | biostudies-arrayexpress
TranscriptomicsComparison of Invasive TAM sub-population to General TAM population
The tumor microenvironment modifies the malignancy of tumors. In solid tumors this environment is populated by many macrophages (tumor-associated macrophages; TAMs) that in genetic studies that depleted these cells from mouse models of breast cancer were shown to promote tumor progression to maligna...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-18295 | biostudies-arrayexpress
TranscriptomicsHighly Aneuploid Zebrafish Malignant Peripheral Nerve Sheath Tumors have Genetic Alterations Similar to Human Cancers
Aneuploidy is a hallmark of human cancers, but most mouse cancer models lack the extensive aneuploidy seen in many human tumors. The zebrafish is becoming an increasingly popular model for studying cancer. Here we report that malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish ...
ORGANISM(S): Danio rerio 
2010-09-08 | E-GEOD-23666 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell lines from 9 different cancer tissue (NCI-60) (U133 platform)
Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel Experiment Overall Design: cell lines from 9 different cancer tissue of origin types
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5720 | biostudies-arrayexpress
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile (miEP) of myb-silenced CD34+ HPCs
The transcription factor cMyb plays a key role in human primary CD34+ hematopoietic progenitor cells (HPCs) lineage choice, by enhancing erythropoiesis at the expense of megakaryopoiesis. We previously demonstrated that cMyb affects erythroid versus megakaryocyte lineage decision in part by transact...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-60300 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bursa of Fabricius from genetically resistant and susceptible chickens infected with Infectious Bursal Disease Virus (IBDV)
We used a chicken immune-targeted gene array to analyse the differences in gene expression in the bursa of Fabricius from genetically resistant and susceptible animals infected with Infectious Bursal Disease Virus (IBDV).
ORGANISM(S): Gallus gallus 
2006-10-19 | E-MEXP-756 | biostudies-arrayexpress
ProteomicsExploiting ECM signatures associated with human metastases for targeting tumors and metastases using alpaca-derived nanobodies
Jailkhani N, Clauser KR, Mak H, Rickelt S, Tian C, Whittaker CA, Tanabe KK, Purdy SR, Carr SA, and Hynes RO.2022. Metastases are hard to detect and treat, and cause most cancer-related deaths. The relative lack of therapies targeting metastases represents a major unmet clinical need. The extracellul...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-28 | MSV000089136 | MassIVE
Sort   by:  
 Page size