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UnknownMyoclonus in older Cavalier King Charles Spaniels.
Not available
S-EPMC9151451 | biostudies-literature
ProteomicsExtracellular Matrix Signatures of Human Primary Metastatic Colon Cancers and their Liver Metastases
Naba A, Clauser KR, Whittaker CA,Carr SA, Tanabe KK, Hynes RO. 2014
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-02-20 | MSV000078555 | MassIVE
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer
This SuperSeries is composed of the following subset Series: GSE23873: Stage-specific sensitivity to p53 restoration in lung cancer: cell line data GSE23874: Stage-specific sensitivity to p53 restoration in lung cancer: tumor data Refer to individual Series
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23875 | biostudies-arrayexpress
TranscriptomicsComparison of Invasive TAM sub-population to General TAM population
The tumor microenvironment modifies the malignancy of tumors. In solid tumors this environment is populated by many macrophages (tumor-associated macrophages; TAMs) that in genetic studies that depleted these cells from mouse models of breast cancer were shown to promote tumor progression to maligna...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-18295 | biostudies-arrayexpress
TranscriptomicsHighly Aneuploid Zebrafish Malignant Peripheral Nerve Sheath Tumors have Genetic Alterations Similar to Human Cancers
Aneuploidy is a hallmark of human cancers, but most mouse cancer models lack the extensive aneuploidy seen in many human tumors. The zebrafish is becoming an increasingly popular model for studying cancer. Here we report that malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish ...
ORGANISM(S): Danio rerio 
2010-09-08 | E-GEOD-23666 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts (MEFs) trisomic for chromosomes 1, 13, 16 and 19
Aneuploidy, an incorrect chromosome number, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes. ...
ORGANISM(S): Mus musculus 
2008-11-15 | E-GEOD-12501 | biostudies-arrayexpress
TranscriptomicsA transcriptional and metabolic signature of primary aneuploidy is present in chromosomally-unstable cancer cells and informs clinical prognosis
In all primary cells analyzed to date, aneuploidy is associated with poor proliferation. Yet, how abnormal karyotypes affect cancer – a disease characterized by both aneuploidy and heightened proliferative capacity – is largely unknown. Here, I demonstrate that the transcriptional alterations caus...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-49894 | biostudies-arrayexpress
TranscriptomicsSIRT7 suppresses tumorigenesis by attenuating MYC activity
SIRT7 is a member of the mammalian sirtuin family of NAD+ dependent deacylases, and interacts with RNA polymerase I and UBF to regulate rDNA transcription. Various studies in mammalian cells and human clinical data have linked SIRT7 to cancer. However studies differ as to whether SIRT7 is oncogen...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-50076 | biostudies-arrayexpress
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: cell line data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23873 | biostudies-arrayexpress
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: tumor data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23874 | biostudies-arrayexpress
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