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MetabolomicsRA-MAP: mapping the molecular immunological landscape in early rheumatoid arthritis with vaccine controls

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of RA, we performed comprehensive clinical and molecu...

2021-06-16 | MTBLS1497 | MetaboLights
TranscriptomicsRNA-seq of human peripheral blood mononuclear cells following oral cholera vaccination
In this study we performed RNA-seq to identify human transcriptomic signatures associated with antibody responses to an oral cholera vaccine. We isolated total RNA from peripheral blood mononuclear cells of vaccinated volunteers who following two priming oral immunisations, had either strong or no a...
ORGANISM(S): Homo sapiens 
2021-03-23 | E-MTAB-9069 | biostudies-arrayexpress
ProteomicsOocyte-Inspired Universal Whole-Cell Vaccines Against Tumor Heterogeneity
Inspired by the zona pellucida, an extracellular armor that safeguards the oocyte, we engineered a biomimetic whole-tumor-cell vaccine whose mechanical properties can be precisely tuned while preserving the full spectrum of native tumor antigens.
ORGANISM(S): Mus Musculus 
2026-03-20 | PXD075990 |
TranscriptomicsTranscription profiling of human peripheral blood monocytes from volunteers in a malaria vaccine trial
Volunteers were assessed at study entry, the day of the third vaccination and 24, 72 hours, two weeks after vaccination, and 5 days after challenge. 13/39 vaccinees were protected and 26/39 were not protected. Eleven vaccinees exhibited delayed onset of parasitemia. All infectivity controls develope...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-18323 | biostudies-arrayexpress
TranscriptomicsSystems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis
Here we applied a systems approach to define human innate immune signatures following MRKAd5/HIV immunization and to analyze the effects of pre-existing Ad5 immunity. We defined the global early immune response to MRKAd5/HIV by profiling the PBMC transcriptomes from seven Ad5Neg individuals pre- and...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22768 | biostudies-arrayexpress
TranscriptomicsProfiling 20,077 genes in 25 vaccine recipients: U133 Plus 2.0, Custom CDF Version 9
The immune responses generated by YF-17D by profiling 20,077 genes in 25 vaccine recipients were accessed at days 1, 3, 7, and 21 post-vaccination compared to pre-vaccination in PBMCs. The immune responses generated by YF-17D by profiling 20,077 genes in 25 vaccine recipients were accessed at days ...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-13485 | biostudies-arrayexpress
TranscriptomicsAffect of antiviral ribavirin on YFV WT and vaccine strains.
Live-attenuated viral vaccines have been successfully used to combat infectious disease for decades but due to their empirical derivation, little is known about their mechanisms of attenuation. This lack of understanding makes the development of next generation live attenuated vaccines difficult. Th...
ORGANISM(S): Yellow fever virus 
2020-01-01 | E-MTAB-8504 | biostudies-arrayexpress
GenomicsSequence of pneumococcal whole cell vaccine strain RM200
Draft annotated genome of pneumococcal whole cell vaccine strain Streptococcus pneumoniae RM200
PRJEB24733 | ENA
TranscriptomicsTrivalent Inactivated Influenza Vaccine (TIV) and Live Attenuated Influenza Vaccine (LAIV) Induce Different B cell and Transcriptional Responses in Children
LAIV and TIV are effective for prevention of influenza infection in children, but the mechanisms associated with protection are still not well defined. We analyzed the differences in B cell responses and transcriptional profiles. Compared to baseline, LAIV elicited a significant increase in naM-CM-/...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52005 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of whole blood from healthy adult volunteers before and after receiving non-live vaccines including seasonal influenza or pneumococcal vaccine or placebo (saline) injections.
The objective of this study is to: 1) Characterize the immune responsiveness to administration of non-live vaccines in three cohorts of healthy adult subjects through the analysis of blood leukocytes transcriptional profiles. 2) Validate whole blood transcriptional profiles generated from standard 3...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-30101 | biostudies-arrayexpress
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