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TranscriptomicsActivating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1-ETO-induced DNA damage in human cells
REtr causes genomic instability in human CD34+ cells. Activated forms of c-KIT, like c-KIT(N822K), rescue the REtr-induced genomic instability by increasing the rate of DNA repair by homologous recombination. Human CD34+ hematopoietic progenitor cells were transduced with retroviral vectors encoding...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-58041 | biostudies-arrayexpress
TranscriptomicsWhole blood expression profiling from a general population (KORA F4)
The development of whole genome association studies from the general population has lead to the robust identification of several loci involved in different common human diseases. Interestingly, most of the strongest signals of association observed in these studies arise from non-coding regions, rais...
ORGANISM(S): Homo sapiens 
2013-07-13 | E-MTAB-1708 | biostudies-arrayexpress
UnknownEnhanced potency of immunotherapy against B-cell precursor acute lymphoblastic leukemia by combination of an Fc-engineered CD19 antibody and CD47 blockade.
Not available
S-EPMC10883238 | biostudies-literature
UnknownGenome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.
Not available
S-EPMC3305829 | biostudies-literature
UnknownLifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.
Not available
S-EPMC2500189 | biostudies-literature
UnknownDual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages.
Not available
S-EPMC9647079 | biostudies-literature
UnknownMitochondrial DNA variants in obesity.
Not available
S-EPMC4008486 | biostudies-literature
UnknownOn the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.
Not available
S-EPMC2427172 | biostudies-literature
GenomicsChIPseq - The ETO2 scaffolding factor maintains acute leukemia by driving a MYB/EP300-dependent oncogenic program
Analysis of ETO2, MYB, EP300 binding as well as H3K27ac, H3K4me1 and H3M27me3 occupancy by ChIP-seq in HEL cells treated with DMSO or dCBP-1 (0.5uM) for 3h or expressing shRNA targeting MYB (shMYB) or genetically inactivated for ETO2 (ETO2ko)
ORGANISM(S): Homo sapiens 
2023-07-06 | E-MTAB-13151 | biostudies-arrayexpress
UnknownEngineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes.
Not available
S-EPMC11194515 | biostudies-literature
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