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ProteomicsCerebrospinal fluid proteomic profiling in nusinersen-treated patients with spinal muscular atrophy Cerebrospinal fluid proteomic profiling in nusinersen-treated patients with spinal muscular atrophy
Promising results from recent clinical trials on the approved antisense oligonucleotide nusinersen in pediatric patients with 5q-linked spinal muscular atrophy (SMA) still have to be confirmed in adult patients but are hindered by a lack of sensitive biomarkers that indicate an early therapeutic res...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD016757 | Pride
Mass spectrometry (ms) Proteomics Antisense oligonucleotide (aso) Nusinersen Spinal muscular atrophy (sma) Cerebrospinal fluid (csf) 
ProteomicsProteomic characterization of cerebrospinal fluid in patients with brain malignancies
Recent technological advances in molecular diagnostics through liquid biopsies hold the promise to monitor tumor evolution and treatment response of brain malignancies without the need of invasive surgical tissue accrual. Here, we implemented a new mass spectrometry-based protein analysis pipeline a...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD021984 | Pride
Brain tumor Glioblastoma Proteome Biomarker 
UnknownDoes Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
Not available
S-EPMC5070573 | biostudies-literature
UnknownPatients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
Not available
S-EPMC5015426 | biostudies-literature
ProteomicsA clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. The determination of TM-interconnectivity in individual tumors has been challenging and the impact on patient survival unresolved. Here, a connectivity signature from si...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD044001 | Pride
Gene expression signature Glioblastoma Connectivity Tumor microtubes Single-cell rna-sequencing 
ProteomicsLongitudinal Proteomic Fingerprinting in CSF of Nusinersen-Treated Patients with 5q-Associated Spinal Muscular Atrophy
Abstract Introduction: 5q-associated spinal muscular atrophy (SMA) is a motor neuron disease causing progressive alpha motor neuron degeneration, muscle atrophy, and weakness. Intrathecal therapy with the antisense oligonucleotide Nusinersen modifies the disease course. However, biomarkers for under...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054900 | Pride
Cerebrospinal fluid Tmt Nusinersen Spinal muscle atrophy Sma Csf 
TranscriptomicsPatients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial
The AVAglio and RTOG-0825 randomized, placebo-controlled phase III trials in newly diagnosed glioblastoma reported prolonged progression-free survival (PFS), but not overall survival (OS), with the addition of bevacizumab to radiotherapy/temozolomide. To establish whether certain patient subgroups d...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-84010 | biostudies-arrayexpress
Genomicsbe40ebac-acee-4026-a661-4330bb0f657b - samples
Bam files for 124 samples (62 tumor vs blood pairs); Whole Genome Sequencing performed on Illumina HiSeq X Ten
EGAD00001005061 | EGA
Genomicsbc246e56-19ea-4c30-9e33-160ac12c3050 - samples
Bam files for 16 meningioma tumor samples; ChIPseq performed on Illumina HiSeq 2000
EGAD00001005021 | EGA
GenomicsMutational patterns and regulatory networks in epigenetic subgroups of meningioma (H033)
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign-1, 2, 3, intermediate-A, B and malignant. Here, we set out to identify subgroup-specific mutational patterns and pathway regulation. Whole-gen...
EGAS00001003481 | EGA
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