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ProteomicsPrognostic value of molecular intratumor heterogeneity in primary oral cancer and its lymph node metastases assessed by mass spectrometry imaging
Different aspects of intra-tumor heterogeneity (ITH), which are associated with development of cancer and its response to treatment, have postulated prognostic value. Here we searched for the potential association between phenotypic ITH analyzed by mass spectrometry imaging (MSI) and the prognosis o...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034958 | Pride
Cancer prognosis  head and neck squamous cell carcinoma  intratumor heterogeneity  long-term outcome  mass spectrometry imaging  tumor microenvironment 
ProteomicsRadiation-induced bystander effect mediated by exosomes involves the replication stress in recipient cells
Exosomes secreted by irradiated cells mediate radiation-induced bystander effect, which is manifested by DNA breaks detected in recipient cells, yet the specific mechanism responsible for the generation of chromosome lesions remains unclear. In this study, naïve FaDu head and neck cancer cells were ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-31 | PXD032080 | Pride
Bystander effect Exosomes Mass spectrometry Q exactive plus Phosphoproteomics 
ProteomicsRadiation-induced bystander effect mediated by exosomes involves the replication stress in recipient cells.
Exosomes released by irradiated cells mediate radiation-induced bystander effect, which is manifested by DNA breaks detected in recipient cells, yet the specific mechanism responsible for generation of chromosome lesions remains unclear. In this study, naïve FaDu head and neck cancer cells were stim...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD032143 | Pride
Bystander effect  exosomes  ionizing radiation  non-targeted effects of radiation  replication stress 
ProteomicsMolecular profiling of tumor-derived exosomes in plasma of patients with melanoma
By isolation of exosomes from body fluids such as serum or plasma with the use of a gel filtration method developed for this purpose, we showed that the level of exosomes in patients with melanoma is higher and may be associated with progression of the tumor and treatment response. By applying the t...
ORGANISM(S): Homo sapiens (Human) 
2021-08-12 | PXD021285 | Pride
Melanoma cell-derived exosomes (mtex) Proteomics High-resolution mass spectrometry (hrms) Tumor-derived exosomes (tex) Plasma Small extracellular vesicles (sev) Human 
GenomicsSubsets of NFkappaB-dependent genes are differentially regulated after combined treatment with hyperthermia and cytokine
Heat shock transcription factor 1 (HSF1) is responsible for triggering stress-induced activation of the HSP genes. HSF1 is also involved in the regulation of many other genes associated with multiple cellular processes including cell signaling, development, fertility, cell death and metabolism, e.g....
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-60984 | biostudies-arrayexpress
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