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TranscriptomicsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARFBP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required for growth of colorecta...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-59223 | biostudies-arrayexpress
TranscriptomicsInfluence of BEZ235 and MYC on gene expression in SW620 cells
SW620 were transfected with siMYC or siCTR at time point 0h. 24h later cells were splitter 1:2, additional 24 h later (48h after transfection) cells were treated with BEZ235 (200nM) or DMSO. Cells were harvested after additional 24h (72h after siRNA transfection; 24h BEZ235 treatment.
ORGANISM(S): Homo sapiens 
2015-08-27 | E-MTAB-2882 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression regulation in LS174T cells transduced with either ERK-dimerization inhibitory peptide or control
Microarray analysis of gene expression regulation in LS174T cells transduced with either ERK-dimerization inhibitory peptide or control.
ORGANISM(S): Homo sapiens 
2020-02-03 | E-MTAB-8111 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression regulation in murine hearts treated with an ERK-dimerization inhibitory peptide gene therapy or control after transverse aortic constriction
This study identifies gene expression changes in murine hearts after TAC surgery and in response to gene therapy with ERK-dimerization inhibitory peptide
ORGANISM(S): Mus musculus 
2020-02-03 | E-MTAB-8110 | biostudies-arrayexpress
UnknownMaintenance of p-eIF2alpha levels by the eIF2B complex is vital for colorectal cancer
Not available
S-SCDT-10_1038-S44318-025-00381-9 | biostudies-other
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