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TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67846 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67845 | biostudies-arrayexpress
GenomicsDissection of the molecular complexity of colorectal cancer in pre-clinical models identifies predictive signatures of sensitivity to EGFR inhibitors
Colorectal carcinoma (CRC) is a heterogeneous tumour entity, with only a fraction of the tumours responding to currently available therapies. A detailed understanding of the biology and genetics of CRC is a prerequisite for precision medicine. To address this challenge in clinical oncology, the Onco...
EGAS00001001752 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:01:24:124-96 - samples
RNAseq on Illumina HiSeq2000/2500 of WNT reporter of PDO culture derived from colorectal cancer metastasis sample
EGAD00001002074 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:08:19:631-106 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of colorectal cancer metastasis sample
EGAD00001002084 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:21:37:629-120 - samples
Whole-exome sequencing on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer metastasis sample
EGAD00001002098 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:25:47:437-127 - samples
Whole-exome sequencing on AB 5500xl Genetic Analyzer of colorectal cancer metastasis sample
EGAD00001002105 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:10:37:045-110 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of colorectal cancer primary tumor sample
EGAD00001002088 | EGA
Genomicsena-DATASET-MPIMG-15-06-2017-11:16:33:021-1359 - samples
RNAseq on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer metastasis sample (OT2_cohort)
EGAD00001003366 | EGA
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