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ProteomicsThe FFPE samples of the primary vs. recurrent glioblastoma validation cohort
The FFPE samples of the primary vs. recurrent glioblastoma validation cohort
ORGANISM(S): Homo Sapiens 
2022-08-08 | PXD035867 |
TranscriptomicsMethylation data from glioblastoma tumor samples
Glioblastoma (GBM) is an incurable brain tumor carrying a dismal prognosis, which displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical positions of histone H3.3 (K27, G34) in one-third of pediatric GBM. Here we show that each of these H3F3...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-36278 | biostudies-arrayexpress
TranscriptomicsIntegrated epigenetic and copy-number profiling identifies three clinically and biologically relevant groups of anaplastic glioma
The outcome of patients with anaplastic gliomas varies considerably depending on histology and single molecular markers such as codeletion of 1p/19q and mutations of the isocitrate dehydrogenase (IDH) gene. Whether a molecularly-based classification of anaplastic gliomas based on large scale genomic...
ORGANISM(S): Homo sapiens 
2014-06-06 | E-GEOD-58218 | biostudies-arrayexpress
TranscriptomicsSuppression of antitumor immunity by the oncometabolite 2-hydroxyglutarate
Isocitrate dehydrogenase (IDH) mutations, a hallmark of gliomagenesis, result in the production of the oncometabolite R-2-hydroxyglutarate (R-2-HG) which is thought to promote tumorigenesis via DNA methylation. Here we identify an additional immunosuppressive activity of R-2-HG: Tumor cell-derived R...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-84849 | biostudies-arrayexpress
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