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UnknownPatient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers.
Not available
S-EPMC8134568 | biostudies-literature
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
ProteomicsPeptidylprolyl isomerase A (PPIA) protein complex
Identification of PPIA protein complex using wild type and mutant cell lines.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-05-27 | MSV000083867 | MassIVE
UnknownWild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
Not available
S-EPMC8113883 | biostudies-literature
GenomicsLarge conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a (CMS bisulfite-seq)
Gains and losses in DNA methylation are prominent genomic features of all mammalian cell types. To gain insight into mechanisms that could promote shifts in DNA 5-hydroxymethylation (5hmc) patterns and thus contribute to cell fate, including malignant transformation, we performed genome-wide mappin...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-53742 | biostudies-arrayexpress
TranscriptomicsTestosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice
Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin (KISS1) do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods. Using micro-disse...
ORGANISM(S): Mus musculus 
2011-08-21 | E-GEOD-28383 | biostudies-arrayexpress
MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
UnknownStructure and biological roles of Sinorhizobium fredii HH103 exopolysaccharide.
Not available
S-EPMC4270759 | biostudies-literature
UnknownFLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells.
Not available
S-EPMC12824609 | biostudies-literature
UnknownDefining incidence and complications of fibrolamellar liver cancer through tiered computational analysis of clinical data.
Not available
S-EPMC10034241 | biostudies-literature
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