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MetabolomicsGNPS - Lipidomics of homeoviscous adaptation to low temperatures in Staphylococcus aureus utilizing exogenous straight-chain unsaturated fatty acids over biosynthesized endogenous branched-chain fatty acids
It is well established that Staphylococcus aureus can incorporate exogenous straight-chain unsaturated fatty acids (SCUFAs) into membrane phospho- and glyco-lipids from various sources in supplemented culture media, and when growing in vivo in an infection. Given the enhancement of membrane fluidity...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2024-05-10 | MSV000094738 | GNPS
TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
MetabolomicsGNPS - Defective pgsA contributes to increased membrane fluidity and cell wall thickening in S. aureus with high-level daptomycin resistance
Daptomycin is a membrane-targeting last-resort antimicrobial therapeutic for the treatment of infections caused by methicillin- and/or vancomycin-resistant Staphylococcus aureus. In the rare event of failed daptomycin therapy, the source of resistance is often attributable to mutations directly with...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2023-04-12 | MSV000091690 | GNPS
MetabolomicsGNPS Revealing fatty acid heterogeneity in Staphylococcal lipids with isotope labeling and RPLC-IM-MS
Up to 80% of the fatty acids in Staphylococcus aureus membrane lipids are branched, rather than straight-chain, fatty acids. The branched fatty acids (BCFAs) may have either an even or odd number of carbons and the branch position may be at the penultimate carbon (iso) or the antepenultimate (anteis...
ORGANISM(S): Staphylococcus Aureus 
2021-05-03 | MSV000087356 | GNPS
UnknownTop 10 priorities for future infertility research: an international consensus development study†  ‡.
Not available
S-EPMC7744161 | biostudies-literature
UnknownEffects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT.
Not available
S-EPMC11873788 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownEffect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.
Not available
S-EPMC8492020 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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