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GenomicsIdentification of the primary target of the chemotherapeutic agent CX-5461 as a late step in transcription initiation by RNA Polymerase I
In recent years, several small molecule cytotoxic drugs have been identified as potential inhibitors of ribosome biogenesis (Drygin et al., 2011; Peltonen et al., 2014a; Peltonen et al., 2014b). CX-5461 is one such drug that has also demonstrated anticancer potential for a wide range of malignancies...
ORGANISM(S): Mus musculus 
2021-04-07 | E-MTAB-9242 | biostudies-arrayexpress
UnknownBronchopulmonary Penetration of Isavuconazole in Pulmonary Transplant Recipients (PBISA01): Protocol for a Phase IV Clinical Trial With a Single Treatment Arm.
Not available
S-EPMC9520388 | biostudies-literature
ClinicalArginase-1 Peptide Vaccine in Patients With Metastatic Solid Tumors
In this phase I first-in-humans-study a vaccine consisting of arginase-1 (ARG1) peptides and the adjuvant Montanide ISA-51 will be tested in ten patients with metastatic solid tumors. Patients will be treated with an ARG1 vaccine every third week for 45 weeks.
2285526 | ecrin-mdr-crc
UnknownOverexpression of Water-Responsive Genes Promoted by Elevated CO2 Reduces ROS and Enhances Drought Tolerance in Coffea Species.
Not available
S-EPMC9966387 | biostudies-literature
UnknownInfochemical use and dietary specialization in parasitoids: a meta-analysis.
Not available
S-EPMC5496531 | biostudies-literature
UnknownGenome-wide expert annotation of the epigenetic machinery of the plant-parasitic nematodes Meloidogyne spp., with a focus on the asexually reproducing species.
Not available
S-EPMC5934874 | biostudies-literature
UnknownResistance in the Genus Spodoptera: Key Insect Detoxification Genes.
Not available
S-EPMC8230579 | biostudies-literature
UnknownMolecular characterization of genes encoding isoamylase-type debranching enzyme in tuberous root of sweet potato, Ipomoea batatas (L.) Lam.
Not available
S-EPMC6587035 | biostudies-literature
UnknownMulti-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, ScaleSF.
Not available
S-EPMC8786651 | biostudies-literature
UnknownThe Venom of the Ectoparasitoid Wasp Pachycrepoideus vindemiae (Hymenoptera: Pteromalidae) Induces Apoptosis of Drosophila melanogaster Hemocytes.
Not available
S-EPMC7349765 | biostudies-literature
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