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TranscriptomicsGene expression profiling of CD4+ T cells infiltrating human breast cancer (Discovery Set)
CD4+ helper T (Th) cells are critical regulators of immune responses but their role in breast cancer is currently unknown. This work aims to characterize Th cells infiltrating invasive primary human breast tumors, analyze the influence by the tumor microenvironment and identify Th cell specific prog...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36765 | biostudies-arrayexpress
TranscriptomicsEffect of human breast tumor supernatant on normal CD4+ T cells (Confirmation Set SN)
CD4+ helper T (Th) cells are critical regulators of immune responses but their role in breast cancer is currently unknown. This work aims to characterize Th cells infiltrating invasive primary human breast tumors, analyze the influence by the tumor microenvironment and identify Th cell specific prog...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36766 | biostudies-arrayexpress
TranscriptomicsHIV-1 TAT SUPPRESSES THE TCR/CD3 MACHINERY IN HUMAN CD4+ T CELLS
Our previous work demonstrated that HIV-1 infection progressively reduces TCR/CD3 expression due to a defect in CD3g gene transcripts. We further found that knocking down expression of the viral tat and/or nef genes was correlated with CD3g transcript and TCR/CD3 surface receptor levels on HIV-1 inf...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-32626 | biostudies-arrayexpress
TranscriptomicsHIV-1 TAT SUPPRESSES THE TCR/CD3 MACHINERY IN HUMAN CD4+ T CELLS [HIV]
Our previous work demonstrated that HIV-1 infection progressively reduces TCR/CD3 expression due to a defect in CD3g gene transcripts. We further found that knocking down expression of the viral tat and/or nef genes was correlated with CD3g transcript and TCR/CD3 surface receptor levels on HIV-1 inf...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-33706 | biostudies-arrayexpress
TranscriptomicsHIV-1 TAT SUPPRESSES THE TCR/CD3 MACHINERY IN HUMAN CD4+ T CELLS [Tat]
Our previous work demonstrated that HIV-1 infection progressively reduces TCR/CD3 expression due to a defect in CD3g gene transcripts. We further found that knocking down expression of the viral tat and/or nef genes was correlated with CD3g transcript and TCR/CD3 surface receptor levels on HIV-1 inf...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-33705 | biostudies-arrayexpress
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