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TranscriptomicsOncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome
Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is a malignancy of mature, skin-homing T cells. Sézary syndrome (Sz) is often considered to represent a leukemic phase of MF. In this study the pattern of numerical chromosomal alterations in MF tumor samples was defined usin...
ORGANISM(S): Homo sapiens 
2008-09-29 | E-GEOD-12902 | biostudies-arrayexpress
TranscriptomicsGenome-wide SNP analysis of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients
The risk of developing cutaneous squamous cell carcinoma (SCC) is markedly increased in organ transplant recipients (OTRs) compared to the normal population. Next to sun exposure, the immunosuppressive regimen is an important risk factor for SCC development in OTRs. Various gene mutations (e.g. TP53...
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-32969 | biostudies-arrayexpress
TranscriptomicsNovel and highly recurrent chromosomal alterations in Sézary syndrome
This study was designed to identify highly recurrent genetic alterations typical of Sézary syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing pathogenetic mechanisms and novel therapeutic targets. High-resolution array-based comparative genomic hybridization was don...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16384 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients
The risk of developing cutaneous squamous cell carcinoma (SCC) is markedly increased in organ transplant recipients (OTRs) compared to the normal population. Next to sun exposure, the immunosuppressive regimen is an important risk factor for the development of SCC in OTRs. Various gene mutations (e....
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-32628 | biostudies-arrayexpress
TranscriptomicsGenome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma
The implication of epigenetic alterations in the pathogenesis of melanoma is increasingly recognized. Here we performed genome-wide DNA methylation analysis of primary cutaneous melanoma and benign melanocytic naevus interrogating 14,495 genes using beadchip technology. This first genome-wide view o...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-45266 | biostudies-arrayexpress
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